# US 10,767,199 B2 · Enzymatic preparation of Propamocarb

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- Number: US 10,767,199 B2
- Document ID: US10767199B2
- Status: Granted
- Kind: B2
- Application number: 16/344,631
- Filed: 2017-10-25
- Published: 2019-10-03
- Granted: 2020-09-08
- Earliest claimed: 2016-10-31
- Assignees: Eastman Chemical Company
- Applicants: Eastman Chemical Company
- Inventors: Stephanie Kay Clendennen; Neil Warren Boaz; Jean-Michel Rabasse
- Web page: https://patentgrep.com/patent/US10767199B2

## CPC

- C12P 13/001: {Amines; Imines}
- C12N 9/20: Triglyceride splitting, e.g. by means of lipase
- C12P 13/02: Amides, e.g. chloramphenicol {or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes (peptides C12P21/00 or C07K)}
- C12Y 301/01003: Triacylglycerol lipase (3.1.1.3)
- C12P: FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {(brewing of beer C12C; producing vinegar C12J; producing specific peptides or proteins C07K; producing enzymes C12N9/00; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; measuring or testing processes involving enzymes or microorganisms C12Q; measuring or testing processes involving nucleic acid amplification reactions C12Q1/6844; fermentation processes to form a food composition, A21 or A23; compounds in general, see the relevant compound class, e.g. C01, C07)}
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C12Y: ENZYMES

## Abstract

A process for preparing Propamocarb is presented. The preparation of Propamocarb (propyl 3-(dimethylamino)propylcarbamate) from 3-dimethylaminopropylamine and dipropyl carbonate is performed using an enzyme catalyst. In certain embodiments, the catalyst is a lipase enzyme, immobilized on a solid support. Advantages of the process include the avoidance of the use of chloroformate or vinyl carbonate.

## Claims

### Claim 1

A process for preparing propyl-3-(dimethylamino)propylcarbamate comprising contacting dipropylcarbonate with 3-dimethylaminopropylamine in the presence of at least one enzymatic catalyst, wherein said catalyst comprises a lipase enzyme.

### Claim 2 (depends on 1)

The process of claim 1, wherein the lipase enzyme is selected from the group consisting of Pseudomonas fluorescens lipase, Pseudomonas capecia lipase, Porcine pancreatic lipase, Candida antarctica lipase A, Candida antarctica lipase B, Thermomyces lanuginosus lipase, Candida rugose lipase, and Mucor miehel lipase.

### Claim 3 (depends on 1)

The process of claim 1, wherein the enzymatic catalyst is immobilized on a solid support.

### Claim 4 (depends on 3)

The process of claim 3, wherein the solid support is selected from the group consisting of activated carbon, porous polyamide, porous polyethylene, porous polypropylene, porous phenol formalin resin, porous fluoropolymer, porous acrylic resin and porous polystyrene resin.

### Claim 5 (depends on 3)

The process of claim 3 wherein the enzymatic catalyst is Candida antarctica lipase B immobilized on a solid support.

### Claim 6 (depends on 2)

The process of claim 2, wherein the enzymatic catalyst is immobilized on a solid support.

### Claim 7 (depends on 4)

The process of claim 4 wherein the enzymatic catalyst is Candida antarctica lipase B immobilized on a solid support.