US 10,767,185 B2 · Method of preparing porcine circovirus type 2 capsid protein and pharmaceutical composition comprising same

Abstract

The present invention provides a preparation method for PCV2 capsid protein and a pharmaceutical composition containing said capsid protein. The method of the present invention uses a novel arabinose-induced expression vector and thereby improves the synthesis efficiency of said PCV2 capsid protein. On the other hand, the present pharmaceutical composition combines said capsid protein and other favorable components at a proper ratio so that achieves excellent immune-inducing effects.

Claims15

Dependent claims

A composition for preventing porcine circovirus type 2 (PCV2) infection, comprising:

an effective amount of 2.5 to 250 μg/mL PCV2 capsid protein for inducing a protective immune response;
2.5 to 25 μg/mL porcine interferon-α;
2.5 to 25 μg/mL porcine interferon-γ;
and
a pharmaceutically acceptable carrier,
wherein a combination of the porcine interferon-α and the porcine interferon-γ elicits a synergistic humoral response to the PCV2 capsid protein.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/778,062Filed 28 Dec 2015

Published

US 2019/0078101 A114 Mar 2019

Granted

8 Sep 2020

Term ends

Not estimatedThe source records don’t support an estimate.

Classification21 codes

C12N 15/635
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression: externally inducible repressor…
A61K 38/162
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: from virus
A61K 39/12
Medicinal preparations containing antigens or antibodies: viral antigens
A61K 47/42
Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates: proteins; Polypeptides; Degradation products thereof; Derivatives…

Method of preparing porcine circovirus type 2 capsid protein and pharmaceutical composition comprising same

Life of this patent

Method of preparing porcine circovirus type 2 capsid protein and pharmaceutical composition comprising same

Life of this patent

Abstract

Claims15