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US 10,767,183 B2Granted
Combination vectors and methods for treating cancer
AssigneeAmerican Gene Technologies International Inc.
InventorsTyler Lahusen, Mei-Ling Liou, Lingzhi Xiao, Haishan Li, Charles David Pauza
Life of this patent
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Abstract
A composition for treating cancer is disclosed. The composition includes a lentiviral particle and an aminobisphosphonate drug. The lentiviral particle is capable of infecting a target cell, such as a cancer cell, and includes an envelope protein optimized for targeting such target cell and a viral vector. The viral vector includes a small RNA optimized to target an FDPS mRNA sequence. The aminobisphosphonate drug includes zoledronic acid.
Claims24
A viral vector comprising a therapeutic cargo portion, wherein the therapeutic cargo portion comprises:
- a first small RNA sequence that is capable of binding to a first pre-determined complementary mRNA sequence, wherein the first pre-determined complementary mRNA sequence comprises a FDPS mRNA sequence;
- and
- a second small RNA sequence that is capable of binding to a second pre-determined complementary mRNA sequence, wherein the second pre-determined complementary mRNA sequence comprises a CD47 mRNA sequence or a cMyc mRNA sequence.
Dependencies are inferred from the claim text.