# US 10,766,922 B2 · Substituted steroids for the treatment of cancer

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- Number: US 10,766,922 B2
- Document ID: US10766922B2
- Status: Granted
- Kind: B2
- Application number: 16/423,205
- Filed: 2019-05-28
- Published: 2019-09-19
- Granted: 2020-09-08
- Earliest claimed: 2017-12-14
- Assignees: Aquavan Technology Co., Ltd
- Applicants: Aquavan Technology Co., Ltd.
- Inventors: Kuo-Tang Tseng; Hsin Ju Wang; Wen-Hung Chen
- Web page: https://patentgrep.com/patent/US10766922B2

## CPC

- C07J 71/0026: {cyclic ketals}
- A61K 31/575: substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A61K 31/58: containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin (digitoxin {A61K31/7048})
- A61K 36/42: Cucurbitaceae (Cucumber family)
- A61P 35/00: Antineoplastic agents
- C07J 9/00: Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J 71/0005: {Oxygen-containing hetero ring}
- C07J: STEROIDS (seco-steroids C07C)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A compound and pharmaceutically acceptable salts thereof for treating cancer, having a structure represented by the following formula (I) or formula (II): in which X and Y each individually represent: R1, R2, R3, R4, and R5 individually represents hydrogen atom, acyl having 20 or less carbon atoms, alkyl having 20 or less carbon atoms, alkanoyl having 20 or less carbon atoms, aroyl having 20 or less carbon atoms, aryl having 20 or less carbon atoms, aralkyl having 20 or less carbon atoms, sulfonyl having 20 or less carbon atoms, phosphonyl having 20 or less carbon atoms, or haloacyl having 20 or less carbon atoms.

## Claims

### Claim 1

A method for inhibiting a cancer cell proliferation in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable carrier, a pharmaceutically acceptable diluent, a pharmaceutically acceptable excipient, and/or a pharmaceutically acceptable adjuvant and a compound represented by formula (vi):

### Claim 2 (depends on 1)

The method according to claim 1, wherein the cancer cell is a human leukemia cell.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the cancer cell is a human lung cancer cell.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the cancer cell is a human glioblastoma cell.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the cancer cell is a human liver cancer cell.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the cancer cell is a human colorectal cancer cell.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the cancer cell is a human breast cancer cell.