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US 10,766,845 B2Granted
Fluorination of acrylate esters and derivatives
AssigneeVifor (International) AG
InventorYongQi Mu
Life of this patent
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Abstract
The present invention generally relates to processes for converting acrylate esters or a derivative thereof to difluoropropionic acid or a derivative thereof. This process is generally performed using fluorine gas in a hydrofluorocarbon solvent.
Claims17
A continuous process for fluorinating a double bond to form a compound of formula 2 comprising:
- forming a reaction stream comprising a compound of formula 1 dissolved in 2H,3H-decafluoropentane,
- wherein R1 is alkoxy;
- the reaction stream flowing through a continuous fluorination reactor at a flow rate of from about 0.2 mL/minute to about 2 mL/minute and fluorine gas flows through the continuous fluorination reactor at a gas flow rate of from about 0.2 mmol/minute to about 2 mmol/minute;
- whereby reaction of the compound of formula 1 with the fluorine gas forms a compound of formula 2
- wherein R2 is alkoxy, and
- further reacting the compound of formula 2 with an alcohol and a catalyst, wherein the reaction is a transesterification.
3 more elements
Dependencies are inferred from the claim text.