# US 10,766,028 B2 · Reagent mixer and fluid control devices

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- Number: US 10,766,028 B2
- Document ID: US10766028B2
- Status: Granted
- Kind: B2
- Application number: 15/945,738
- Filed: 2018-04-04
- Published: 2018-08-09
- Granted: 2020-09-08
- Earliest claimed: 2014-06-16
- Assignees: Life Technologies Corporation
- Applicants: Life Technologies Corporation
- Inventors: Jonathan Schultz; Todd Roswech
- Web page: https://patentgrep.com/patent/US10766028B2

## CPC

- B01L 3/502: {with fluid transport, e.g. in multi-compartment structures}
- B01F 31/201: {Holders therefor}
- B01F 31/55: the materials to be mixed being contained in a flexible bag submitted to periodical deformation
- B01F 35/71745: {using pneumatic pressure, overpressure, gas or air pressure in a closed receptacle or circuit system}
- B01F 35/7543: {using pneumatic pressure, overpressure or gas pressure in a closed receptacle or circuit system}
- B01L 3/527: {for a plurality of reagents}
- B65D 81/3272: {formed by arranging one flexible container within another}
- G01N 35/1002: {Reagent dispensers}
- B01L 3/505: {Flexible containers without fluid transport within}
- B01L 2200/04: Exchange or ejection of cartridges, containers or reservoirs
- B01L 2200/16: Reagents, handling or storing thereof
- B01L 2300/022: Transponder chips
- B01L 2300/0681: Filter
- B01L 2300/0861: Configuration of multiple channels and/or chambers in a single devices
- B01L 2300/123: Flexible; Elastomeric
- B01L 2400/0481: squeezing of channels or chambers
- B01L 2400/0487: fluid pressure, pneumatics
- Y10T 436/2575: Volumetric liquid transfer
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01F: MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING (mixing paints B44D3/06)
- B65D: CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

An apparatus for preparing a reagent solution includes an enclosure and a container disposed within the enclosure. The container defines an internal cavity having a compressible volume and defines a passage providing fluidic communication between the internal cavity and the exterior of the container. Optionally, a compressible member is disposed within the internal cavity. A reagent is disposed within the internal cavity.

## Claims

### Claim 1

An apparatus comprising:
a case defining a volume and having a gas port; and
a plurality of enclosures disposed within the volume and secured to the case, each enclosure of the plurality of enclosures comprising:
a fluid port providing fluidic access to the interior of the enclosure;
a container disposed within the each enclosure, the container defining an internal cavity having a compressible volume and defining a passage providing fluidic communication between the internal cavity and the exterior of the container, wherein the container includes an insert coupled to a fitting to form the internal cavity; and
a reagent disposed within the internal cavity.

### Claim 2 (depends on 1)

The apparatus of claim 1, further comprising a compressible member disposed within the internal cavity.

### Claim 3 (depends on 2)

The apparatus of claim 2, wherein the compressible member includes a resilient foam.

### Claim 4 (depends on 1)

The apparatus of claim 1, wherein the each enclosure of the plurality of enclosures is secured to the container, the container providing fluidic access to the fluid port of the each enclosure.

### Claim 5 (depends on 1)

The apparatus of claim 1, wherein the container is secured to the enclosure through an arm coupling the container to the enclosure.

### Claim 6 (depends on 1)

The apparatus of claim 1, wherein the enclosure is a bag enclosure.

### Claim 7 (depends on 1)

The apparatus of claim 1, wherein the each enclosure further includes a set of arms coupled to the container to position the container approximately centrally within the enclosure.

### Claim 8 (depends on 1)

The apparatus of claim 1, wherein the reagent of the each enclosure includes a unique lyophilized nucleotide or an analog thereof, a nucleotide solution, or a pH-adjusting solution.

### Claim 9 (depends on 1)

The apparatus claim 1, further comprising a flange coupled to the container and the fluid port.