# US 10,766,003 B2 · Presterilizable filtration system to be disposed of after a single use > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,766,003 B2 - Document ID: US10766003B2 - Status: Granted - Kind: B2 - Application number: 12/933,433 - Filed: 2009-03-13 - Published: 2011-01-13 - Granted: 2020-09-08 - Earliest claimed: 2008-03-20 - Assignees: Sartorius Stedim Biotech GmbH - Applicants: Lars Boettcher; Frank Guthof; Jan Schaefer; Isabelle Gay - Inventors: Lars Boettcher; Frank Guthof; Jan Schaefer; Isabelle Gay - Web page: https://patentgrep.com/patent/US10766003B2 ## CPC - B01D 61/18: Apparatus therefor - A61M 1/3621: {Extra-corporeal blood circuits (single-needle circuits A61M1/30)} - A61M 1/3603: {in the same direction} - B01D 2313/18: Specific valves - B01D 2313/243: Pumps - B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A presterilizable filtration system is provided and is to be disposed of after a single use. The system has a recirculation tank and a filtration module that are connected to each other in a circuit via a hose system that can be regulated by at least one valve. The valve has a disposable separate valve part that can be integrated in the hose system and a reusable actuator. ## Claims ### Claim 1 A filtration system, comprising: a pre-sterilized subsystem (2) that includes: at least one disposable Container (6); at least one disposable filtration module (7); a disposable hose system (8) connecting the at least one container (6) and the at least one filtration module (7); a disposable pump part (14) integrated into the hose system (8) between the at least one container (6) and the at least one filtration module (7); a disposable, valve part (12) integrated in the hose system (8) and having a variable passage; and a plurality of disposable measuring cells (28) integrated into the hose system (8); and a reusable filtration installation (1) that includes: a reusable pump drive (15) removably associated with the disposable pump part (14) for selectively operating the disposable pump part (14) to control flow through the hose system (8); a reusable actuator (13) removably associated with the disposable valve part (12) and operating the disposable valve part (12) for selectively varying the passage of the disposable valve part (12) to control flow through the hose system (8); reusable transducers (29) removably associated respectively with the disposable measuring cells (12); and a controlling unit (4) connected to the reusable actuator (13), to the reusable transducers (29) and to the reusable pump drive (15) for controlling the disposable pump part (14) and for controlling the reusable actuator (13) and thereby controlling the disposable valve part (12) of the valve (11) and for receiving information from the measuring cells (28), and wherein the at least one container (6), the at least one filtration module (7), the hose system (8), the disposable valve part (12), disposable measuring cells (28) and the disposable pump part (14) are prepackaged in a sterile manner for connection to the reusable actuator (13), the reusable pump drive (15) and the reusable transducers (29). ### Claim 2 (depends on 1) The filtration system according to claim 1, wherein the at least one container (6) is a recirculation tank which, with the at least one filtration module (7) and the hose system (8), forms a circuit (9). ### Claim 3 (depends on 1) The filtration, system according to claim 1, wherein the disposable valve part (12) is as a flap valve, diaphragm valve, ball valve, seat valve or slide valve. ### Claim 4 (depends on 1) The filtration system according to claim 1, wherein the disposable pump part (14) is an exchangeable pump head of a pressure piston pump, rotary piston pump, centrifugal pump or diaphragm pump. ### Claim 5 (depends on 1) The filtration system according to claim 1, wherein the at least one container (6) is a flexible bag. ### Claim 6 (depends on 1) The filtration system according to claim 1, wherein the at least one container (6) is connected to the hose system (8) via a fixed connection, the hose system being configured to be cut by a welding appliance for separating the at least one container (6) from the hose system (8) in a liquid-tight manner. ### Claim 7 (depends on 1) The filtration system according to claim 1, wherein the at least one filtration module (7) has a permeate outlet, and the hose system further comprising a permeate hose line (20) fixedly connected to the permeate outlet for delivering permeate to a permeate tank. ### Claim 8 (depends on 7) The filtration system according to claim 7, further comprising a second a second disposable valve part (12) integrated in the permeate hose line (20) and a second reusable actuator (13) removably associated with the second disposable valve part (12), the second reusable actuator (13) being configured for operating the disposable valve part (12) for selectively varying the passage of the second disposable valve part (12) to control flow of permeate through the permeate hose line (20). ### Claim 9 (depends on 1) The filtration system according to claim 1, wherein the at least one filtration module (7) is dead-end filtration module. ### Claim 10 (depends on 9) The filtration system according to claim 9, wherein the dead-end filtration module (7) is a filter capsule. ### Claim 11 (depends on 2) The filtration system according claim 2, wherein the at least one filtration module (7) is a crossflow filter with tangential feed. ### Claim 12 (depends on 11) The filtration system according to claim 11, wherein the crossflow filter (7) is a stack of membrane cartridges. ### Claim 13 (depends on 1) The filtration system according to claim 1, wherein the at least one filtration module (7) contains filtration membranes in an ultrafiltration or microfiltration range and comprising hollow fibers, flat membranes or membrane adsorbers. ### Claim 14 (depends on 1) The filtration system according to claim 1, wherein the at least one container has a disposable safety valve. ### Claim 15 (depends on 1) The filtration system according to claim 1, wherein all parts of the filtration system are formed from materials that can be sterilized with gamma rays.