# US 10,765,891 B2 · Evaluation of dose accuracy of radiation therapy treatment plans > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,765,891 B2 - Document ID: US10765891B2 - Status: Granted - Kind: B2 - Application number: 16/172,958 - Filed: 2018-10-29 - Published: 2019-05-16 - Granted: 2020-09-08 - Earliest claimed: 2017-11-15 - Assignees: Koninklijke Philips N.V. - Applicants: Koninklijke Philips N.V. - Inventors: Alfonso Agatino Isola; Rolf Jürgen Weese; Christoph Neukirchen; Steffen Renisch; Hrishikesh Narayanrao Deshpande; Heinrich Schulz; Sven Kabus; Stéphane Allaire; Maria Luiza Bondar - Web page: https://patentgrep.com/patent/US10765891B2 ## CPC - A61N 5/1075: {for testing, calibrating, or quality assurance of the radiation treatment apparatus} - A61N 5/103: {Treatment planning systems} - A61N 5/1031: {using a specific method of dose optimization} - A61N 5/1077: {Beam delivery systems} - G16H 20/40: relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture - A61N 2005/1041: {using a library of previously administered radiation treatment applied to other patients} - A61N 2005/1074: {Details of the control system, e.g. user interfaces} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract The invention relates to a system and a method for evaluating a treatment plan for an external radiation therapy treatment, the treatment plan comprising parameters for controlling an external radiation therapy apparatus during the treatment. The system comprises a database storing historic treatment plans and storing for each historic treatment plan a quality parameter indicative of whether a deviation between a planned dose distribution and a measured dose distribution resulting from an execution of the treatment plan is within an acceptable limit. An evaluation unit determines a threshold value for each of a plurality of treatment plan metrics based on the historic treatment plans and the associated quality parameters. Further, the evaluation unit calculates a value of each of the metrics for the treatment plan and compares the value of each of the metrics with the threshold value determined for the respective metric. ## Claims ### Claim 1 A system for evaluating a treatment plan for an external radiation therapy treatment of a patient delivered using an external beam radiation therapy apparatus, the treatment plan comprising parameters for controlling the external beam radiation therapy apparatus during the treatment, the system comprising: a database storing a plurality of historic treatment plans and storing for each historic treatment plan a quality parameter indicative of whether a deviation between a planned dose distribution corresponding to the respective treatment plan and a measured dose distribution resulting from an execution of the treatment plan is within an acceptable limit; and an evaluation unit configured to: determine a threshold value for each of a plurality of treatment plan metrics on a basis of the historic treatment plans and associated quality parameters; calculate a value of each of the plurality of treatment plan metrics for the treatment plan and to compare the value of each of the plurality of treatment plan metrics with the threshold value determined for the respective metric and to provide the result of the calculation and/or the comparison for a validation of the treatment plan; and compare the calculated value of each of the plurality of treatment plan metrics with an associated further flexibility threshold, wherein the value of the flexibility threshold does not comply with the threshold values determined for the metric. ### Claim 2 (depends on 1) The system as defined in claim 1, wherein the evaluation unit is configured to determine the threshold values for the treatment plan metrics on the basis of a statistical analysis of the quality parameters associated with the treatment plans stored in the database. ### Claim 3 (depends on 1) The system as defined in claim 1, wherein the quality parameter associated with a treatment plan comprises an indication of a result of a quality assurance test of the treatment plan and/or gamma indices determined for the treatment plan. ### Claim 4 (depends on 1) The system as defined in claim 1, wherein the database can be updated to store further treatment plans and associated quality parameters and wherein the evaluation unit is configured to adapt the determined threshold values to the further treatment plans upon an update of the database. ### Claim 5 (depends on 1) The system as defined in claim 1, wherein the evaluation unit is configured to receive a threshold value input by a user of the system for at least one of the treatment plan metrics and to compare the calculated value for the respective treatment plan metric with said threshold value instead of the threshold value determined on the basis of the historic treatment plans and the associated quality parameters. ### Claim 6 (depends on 1) The system as defined in claim 1, wherein the evaluation unit is configured to receive a threshold value input by a user of the system for at least one further treatment plan metric, to calculate a value of the further metric for the treatment plan and to compare the calculated value with said threshold value and/or to provide the result of the calculation and/or the comparison for a validation of the treatment plan. ### Claim 7 (depends on 1) The system as defined in claim 1, wherein the evaluation unit is configured to present the calculated values of the metrics to a user of the system in a graphical user interface in order to allow for a validation of the treatment plan by the user. ### Claim 8 (depends on 1) The system as defined in claim 1, wherein the evaluation unit is configured to highlight the calculated values in a graphical user interface based on their compliance with the threshold value determined for the respective metric and/or with the associated flexibility threshold. ### Claim 9 (depends on 1) The system as defined in claim 1, wherein the evaluation unit is configured to present the calculated values of the metrics in a graphical user interface only in case the calculated value of at least one of the metrics is not compliant with its associated threshold value. ### Claim 10 (depends on 9) The system as defined in claim 9, wherein the evaluation unit is configured to automatically accept the treatment plan if the calculated values of all metrics are compliant with their associated thresholds. ### Claim 11 (depends on 1) The system as defined in claim 1, wherein the system is configured to carry out a quality assurance test for the treatment plan if the treatment is accepted as the result of its validation. ### Claim 12 (depends on 1) The system as defined in claim 1, wherein the external beam radiation therapy apparatus comprises a radiation source for generating a radiation beam to be delivered to the patient and a collimator for forming the radiation beam, the treatment plan comprising parameters for controlling the radiation source and/or the collimator during the treatment. ### Claim 13 A method for evaluating a treatment plan for an external radiation therapy treatment of a patient delivered using an external beam radiation therapy apparatus, the treatment plan comprising parameters for controlling the external beam radiation therapy apparatus during the treatment, the method comprising: storing a plurality of historic treatment plans in a database and storing for each historic treatment plan a quality parameter indicative of whether a deviation between a planned dose distribution corresponding to the respective treatment plan and a measured dose distribution resulting from an execution of the treatment plan is within an acceptable limit; determining a threshold value for each of a plurality of treatment plan metrics on a basis of the historic treatment plans and associated quality parameters; calculating a value of each of the plurality of treatment plan metrics for the treatment plan; comparing the value of each of the plurality of treatment plan metrics with the threshold value determined for the respective metric; providing the result of the calculation and/or the comparison for a validation of the treatment plan; and comparing the calculated value of each the plurality of treatment plan metrics with an associated further flexibility threshold, where the value of the flexibility threshold does not comply with the threshold values determined for the metric. ### Claim 14 (depends on 13) The method as defined in claim 13, further comprising: determining the threshold values for the treatment plan metrics on the basis of a statistical analysis of the quality parameters associated with the treatment plans stored in the database. ### Claim 15 (depends on 13) The method as defined in claim 13, wherein the quality parameter associated with a treatment plan comprises an indication of a result of a quality assurance test of the treatment plan and/or gamma indices determined for the treatment plan. ### Claim 16 (depends on 13) The method as defined in claim 13, further comprising: updating the database to store further treatment plans and associated quality parameters, wherein an evaluation unit is configured to adapt the determined threshold values to the further treatment plans upon an update of the database. ### Claim 17 A tangible, non-transitory computer readable medium that stores instructions, which when executed by a processor, cause the processor to: store a plurality of historic treatment plans in a database and store for each historic treatment plan a quality parameter indicative of whether a deviation between a planned dose distribution corresponding to the respective treatment plan and a measured dose distribution resulting from an execution of the treatment plan is within an acceptable limit; determine a threshold value for each of a plurality of treatment plan metrics on a basis of the historic treatment plans and associated quality parameters; calculate a value of each of the metrics for the treatment plan; compare the value of each of the metrics with the threshold value determined for the respective metric; provide the result of the calculation and/or the comparison for a validation of the treatment plan; and compare the calculated value of each the metrics with an associated further flexibility threshold, where the value of the flexibility threshold does not comply with the threshold values determined for the metric. ### Claim 18 (depends on 17) The tangible, non-transitory computer readable medium of claim 17, wherein the instructions, when executed by the processor, further cause the processor to: determine the threshold values for the treatment plan metrics on the basis of a statistical analysis of the quality parameters associated with the treatment plans stored in the database. ### Claim 19 (depends on 17) The tangible, non-transitory computer readable medium of claim 17, wherein the quality parameters associated with a treatment plan comprises an indication of a result of a quality assurance test of the treatment plan and/or gamma indices determined for the treatment plan. ### Claim 20 (depends on 17) The tangible, non-transitory computer readable medium of claim 17, wherein the instructions, when executed by the processor, further cause the processor to: update the database to store further treatment plans and associated quality parameters, wherein an evaluation unit is configured to adapt the determined threshold values to the further treatment plans upon an update of the database.