# US 10,765,879 B2 · Electromagnetic treatment of brain and body disorders > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,765,879 B2 - Document ID: US10765879B2 - Status: Granted - Kind: B2 - Application number: 14/205,333 - Filed: 2014-03-11 - Published: 2014-09-11 - Granted: 2020-09-08 - Earliest claimed: 2013-03-11 - Assignees: NeuroEM Therapeutics, Inc. - Applicants: NeuroEM Therapeutics, Inc. - Inventors: Gary W. Arendash; Jon W. McGarity; Lyle R. Scritsmier - Web page: https://patentgrep.com/patent/US10765879B2 ## CPC - A61N 2/02: using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence) - A61B 5/4836: {Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence)} - A61N 1/40: Applying electric fields by inductive or capacitive coupling (microwave apparatus A61N5/00); {Applying radio-frequency signals} - A61N 2/006: {for magnetic stimulation of nerve tissue} - A61N 5/04: Radiators for near-field treatment - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Disclosed are devices, methods, and systems for helping to prevent (or preventing) or treat brain and/or body disorders. Embodiments of the invention have utility for enhancing cognitive function during aging. The invention utilizes electromagnetic stimulation (EMS) that can provide a range of EMS parameters and modalities. The EMS may be utilized in conjunction with physiologic sensors that can provide feedback for possible EMS modifications. ## Claims ### Claim 1 A device to treat a human subject using electromagnetic stimulation (EMS), comprising: a head unit to be worn on a head region of the human subject, the head unit comprising: a first group of multiple antennae on a first side of the head unit; and a second group of multiple antennae on a second side of the head unit; wherein the head unit is programmed such that each of the multiple antennae in each group is configured to sequentially discharge electromagnetic waves such that no two antennae on a same side of the head discharge simultaneously; a power source connected to the first group and second group; and a control panel connected to the power source and configured to activate the first group and second group to discharge electromagnetic waves to create electromagnetic stimulation (EMS) in the subject's brain at a frequency of between 300 and 3,000 MHz to enhance neuronal function of neurons of the human subject. ### Claim 2 (depends on 1) The device of claim 1 wherein the first and second group each comprise RF antennas. ### Claim 3 (depends on 1) The device of claim 1 wherein the EMS is pulsed. ### Claim 4 (depends on 1) The device of claim 1 wherein the power source is a battery that is either within the device or attached to the device. ### Claim 5 (depends on 1) The device of claim 1, wherein: the multiple antennae are controlled by a single control panel; and the single control panel contains controls for frequency, power level, and modality settings for each antenna. ### Claim 6 (depends on 1) The device of claim 1, wherein multiple antennae are connected to one another. ### Claim 7 (depends on 1) The device of claim 1, wherein the control panel modulates the electromagnetic waves using at least one of GSM-based modulation, UMTS modulation, TETRA modulation, and D-AMPs modulation. ### Claim 8 A method, comprising: providing multiple antennae on either side of a user's head via a head unit with a conforming fabric; and performing transcranial electromagnetic treatment (TEMT) by applying electromagnetic stimulation (EMS) to the user to enhance neuronal function of neurons of the user by: activating the antennae over a predetermined period of time and with given parameter selection; activating antennae to discharge electromagnetic waves at frequencies between 1 megahertz (MHz) and 25 gigahertz (GHz) to create the EMS in a user's brain; and sequentially activating antenna on either side of a brain such that no two antenna are simultaneously transmitting on a given side of the brain. ### Claim 9 (depends on 8) The method of claim 8, wherein activating antenna to frequencies between 1 megahertz (MHz) and 25 gigahertz (GHz) comprises activating antenna to frequencies between 300 and 3,000 MHz. ### Claim 10 (depends on 8) The method of claim 8, wherein activating the antenna to frequencies between 1 megahertz (MHz) and 25 gigahertz (GHz) comprises activating the antenna to frequencies between 902 and 928 megahertz (MHz). ### Claim 11 (depends on 8) The method of claim 8, further comprising automatically deactivating the electromagnetic stimulation after a specified period of time, wherein the electromagnetic stimulation remains off for just a predetermined period of time. ### Claim 12 (depends on 8) The method of claim 8, further comprising: receiving authentication of an administering user; and following authentication, activating the electromagnetic stimulation. ### Claim 13 (depends on 12) The method of claim 12, wherein the authentication is a biometric authentication. ### Claim 14 (depends on 8) The method of claim 8, further comprising: collecting physiological data; and automatically adjusting the parameters of the electromagnetic stimulation based on collected physiological data. ### Claim 15 (depends on 8) The method of claim 8, further comprising modulating the frequencies of the multiple antenna. ### Claim 16 (depends on 8) The method of claim 8, wherein applying electromagnetic stimulation to the user to enhance neuronal function of neurons of the user comprises at least one of: activating the antennae to provide an average specific absorption rate (SAR) ranging from 0.1 to 1.6 W/kg; and activating the antennae to provide an average specific absorption rate (SAR) greater than 1.6 W/kg. ### Claim 17 (depends on 8) The method of claim 8, further comprising selecting an electromagnetic stimulation profile based on a neurologic condition, wherein the electromagnetic stimulation profile comprises: antenna conformation; specific absorption rate value; a wave frequency; a power level; a treatment time; a periodicity; and antenna location. ### Claim 18 (depends on 8) The method of claim 8, wherein applying electromagnetic stimulation to the user to enhance neuronal function of neurons of the user comprises sequentially activating antenna on either side of a brain such that two or more antennae on different sides of the head discharge simultaneously. ### Claim 19 (depends on 8) The method of claim 8, further comprising adjusting the frequency and duration of the electromagnetic stimulation to treat one or more of the following: Alzheimer's Disease (AD), Mixed AD/Vascular Dementia, Cerebral Amyloid Angiopathy, Hemorrhagic Stroke, Multi-Infarct Dementia, Parkinson's Disease, Lewy Body Dementia, Down's Syndrome, Traumatic Brain Injury, Fronto-Temporal Lobe Dementia, Cerebral Traumatic Encephalopathy, Huntington's Disease, and Prion Diseases (Transmissive Spongiform Encephalopathy, Kuru, and Creutzfeldt-Jakob Disease). ### Claim 20 (depends on 8) The method of claim 8, further comprising adjusting the frequency and duration of the electromagnetic stimulation to treat one or more of the following: Amyotrophic Lateral Sclerosis (ALS), mental retardation, stroke, autism, bipolar disorder, schizophrenia, anxiety disorders, mitochondrial encephalomyopathies, epilepsy, migraine headache, and major depression. ### Claim 21 (depends on 8) The method of claim 8, further comprising adjusting the frequency and duration of the electromagnetic stimulation to treat one or more of the following: stroke, Dystonia, and Hemiballismus. ### Claim 22 (depends on 8) The method of claim 8, further comprising adjusting the frequency and power level of the electromagnetic stimulation to treat Age-Associated Memory Impairment (AAMI). ### Claim 23 (depends on 8) The method of claim 8, further comprising modulating the electromagnetic stimulation to enhance normal cognition function. ### Claim 24 (depends on 8) The method of claim 8, further comprising activating the multiple antennae multiple times per day. ### Claim 25 A method, comprising: providing transcranial electromagnetic treatment (TEMT) by: determining an electromagnetic stimulation (EMS) profile based on an affected brain area and a neurological condition to be treated, wherein the EMS profile comprises: a specific absorption rate value between 0.1 to 1.6 W/kg; a wave frequency between 1 megahertz (MHz) and 25 gigahertz (GHz); a power level; a treatment time; and a periodicity; providing multiple antennae on either side of a user's head via a head unit; and applying EMS to a sub-cortical brain area of the user to enhance neuronal function of neurons of the user, ameliorate amyloid protein aggregation, and enhance mitochondrial energy production by: activating the antennae to discharge electromagnetic waves to a user's brain over a predetermined period of time based on the EMS profile; and sequentially activating antenna from arrays on either side of a brain such that no two antenna are simultaneously transmitting on a given side of the brain. ### Claim 26 (depends on 25) The method of claim 25, further comprising: collecting physiological data; and automatically adjusting the frequency and power level of the EMS based on collected physiological data to ameliorate amyloid protein aggregation, enhance mitochondrial energy production, and increase neural activity. ### Claim 27 (depends on 26) The method of claim 26, wherein collected physiological data is selected from the group consisting of electroencephalogram data and scalp temperature. ### Claim 28 (depends on 25) The method of claim 25, wherein: applying EMS to the user comprises activating the antennae multiple times during a particular interval; and the method further comprises: deactivating the multiple antennae after a period of time; and maintaining the multiple antennae deactivated for a predetermined period of time. ### Claim 29 (depends on 25) The method of claim 25, wherein: the EMS profile comprises an EMS modality selected based on an affected brain area and a neurological condition to be treated; and the EMS modality is selected from the group consisting of GSM-based modulation, UMTS modulation, TETRA modulation, and D-AMPs modulation.