# US 10,765,868 B2 · Electrical stimulation device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,765,868 B2 - Document ID: US10765868B2 - Status: Granted - Kind: B2 - Application number: 15/299,723 - Filed: 2016-10-21 - Published: 2017-04-27 - Granted: 2020-09-08 - Earliest claimed: 2015-10-23 - Assignees: GIMER MEDICAL. Co. LTD. - Applicants: GiMer Medical Co., Ltd. - Inventors: Chi-Heng Chang; Jian-Hao Pan - Web page: https://patentgrep.com/patent/US10765868B2 ## CPC - A61N 1/3615: {Intensity} - A61N 1/36071: {Pain} - A61N 1/36125: {Details of circuitry or electric components} - A61N 1/36153: {Voltage (A61N1/3616 takes precedence)} - A61N 1/36171: {Frequency} - A61N 1/36142: {for improving safety} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract The present application discloses am electrical stimulation device for electrically stimulating at least one target zone of an organism. The electrical stimulation device comprises a control unit and an electrical stimulation unit. The electrical stimulation unit includes a frequency synthesizer, an amplifier, a variable resistor, at least one first electrode and at least one second electrode. The frequency synthesizer is coupled to the control unit and generates a frequency signal. The amplifier is coupled to the frequency synthesizer. The variable resistor comprises a resistance and is coupled to the control unit and the amplifier. The first electrode and the second electrode are coupled to the amplifier. The amplifier outputs an electrical stimulation signal according to the frequency signal of the frequency synthesizer and the resistance of the variable resistor to impel the first electrode and the second electrode to generate an electric field. ## Claims ### Claim 1 An electrical stimulation device for electrically stimulating at least one target zone of an organism, comprising a control unit; and an electrical stimulation unit including: a frequency synthesizer which is coupled to the control unit and configured to generate a frequency signal; a summing amplifier which is coupled to the frequency synthesizer; a variable resistor which comprises a resistance and is coupled to the control unit and the summing amplifier; at least one first electrode and at least one second electrode, wherein the first electrode and the second electrode are coupled to the summing amplifier; a pulse generator which is coupled to the control unit and configured to generate a plurality of pulse signals, wherein the plurality of pulse signals include a first pulse wave signal and a second pulse wave signal, a time difference between the first pulse wave signal and the second pulse wave signal is at least 2 micro-seconds; and a differential amplifier which is coupled to the pulse generator and the summing amplifier, and configured to output a biphasic pulse signal according to the plurality of pulse signals, wherein the summing amplifier is configured to output an electrical stimulation signal according to the biphasic pulse signal, the frequency signal of the frequency synthesizer and the resistance of the variable resistor to impel the first electrode and the second electrode to generate an electric field, the electric field covers the target zone, and the electric field strength ranges from 100 V/m to 5000 V/m. ### Claim 2 (depends on 1) The electrical stimulation device according to claim 1, wherein the frequency synthesizer is coupled to an input of the summing amplifier. ### Claim 3 (depends on 2) The electrical stimulation device according to claim 2, wherein the variable resistor is coupled to the input of the summing amplifier. ### Claim 4 (depends on 2) The electrical stimulation device according to claim 2, wherein the variable resistor is coupled to an output of the summing amplifier. ### Claim 5 (depends on 3) The electrical stimulation device according to claim 3, wherein the variable resistor is coupled to an output of the summing amplifier. ### Claim 6 (depends on 1) The electrical stimulation device according to claim 1, wherein the electrical stimulation unit further comprises a filter which is coupled between the frequency synthesizer and the summing amplifier. ### Claim 7 (depends on 1) The electrical stimulation device according to claim 1, wherein the electrical stimulation unit further comprises a surge protector which is coupled to the summing amplifier. ### Claim 8 (depends on 1) The electrical stimulation device according to claim 1, wherein the electrical stimulation device is an implanted electrical stimulation device. ### Claim 9 (depends on 1) The electrical stimulation device according to claim 1, wherein the frequency of the electrical stimulation signal ranges from 200 KHz to 1000 KHz. ### Claim 10 (depends on 1) The electrical stimulation device according to claim 1, wherein the voltage of the electrical stimulation signal is biphasic, and its absolute value is between 3V and 12V. ### Claim 11 (depends on 1) The electrical stimulation device according to claim 1, wherein the biphasic pulse signal comprises a positive phase signal portion, a negative phase signal portion, and an absolute value of a sum of the integrated value of the positive phase signal portion with respect to time and the integrated value of the negative phase signal portion with respect to time is not more than one tenth of the integrated value of the positive phase signal portion with respect to time. ### Claim 12 (depends on 11) The electrical stimulation device according to claim 11, wherein the first pulse wave signal is a positive pulse constituting the positive phase signal portion of the biphasic pulse signal, and the second pulse wave signal is a positive pulse constituting the negative phase signal portion of the biphasic pulse signal by inverting. ### Claim 13 (depends on 1) The electrical stimulation device according to claim 1, wherein the electrical stimulation unit further comprises: a detector coupled to the control unit and the summing amplifier, and configured to detect the electrical stimulation signal. ### Claim 14 (depends on 13) The electrical stimulation device according to claim 13, wherein the control unit detects whether the waveform of the electrical stimulation signal detected by the detector is matched with a preset waveform, the control unit modifies the electrical stimulation signal when the waveform of the electrical stimulation signal deviates from the preset waveform. ### Claim 15 A method applied to electrically stimulate a target zone of an organism by an implanted electrical stimulation device, wherein the implanted electrical stimulation device comprises a frequency synthesizer, a variable resistor, at least a first electrode, at least a second electrode, the method comprising: generating a frequency signal by the frequency synthesizer; generating a plurality of pulse signals, wherein the plurality of pulse signals include a first pulse wave signal and a second pulse wave signal, a time difference between the first pulse wave signal and the second pulse wave signal is at least 2 micro-seconds; outputting a biphasic pulse signal according to the plurality of pulse signals; outputting an electrical stimulation signal according to the biphasic pulse signal, the frequency signal and the resistance of the variable resistor; and delivering the electrical stimulation signal by the first electrode and the second electrode to generate an electrical field between the first electrode and the second electrode to electrically stimulate the target zone, wherein the electric field covers the target zone, and strength of the electric field ranges from 100 V/m to 5000 V/m. ### Claim 16 (depends on 15) The method according to claim 15, wherein the frequency of the electrical stimulation signal ranges from 200 KHz to 1000 KHz. ### Claim 17 (depends on 15) The method according to claim 15, wherein the biphasic pulse signal comprises a positive phase signal part, a negative phase signal part, and an absolute value of a sum of the integrated value of the positive phase signal portion with respect to time and the integrated value of the negative phase signal portion with respect to time is not more than one tenth of the integrated value of the positive phase signal portion with respect to time. ### Claim 18 (depends on 17) The method according to claim 17, wherein the first pulse wave signal is a positive pulse constituting the positive phase signal portion of the biphasic pulse signal, and the second pulse wave signal is a positive pulse constituting the negative phase signal portion of the biphasic pulse signal by inverting. ### Claim 19 (depends on 15) The method according to claim 15, wherein the implanted electrical stimulation device further comprises a detector, and the method further comprises: by a control unit, detecting whether the waveform of the electrical stimulation signal detected by the detector is matched with a preset waveform; by the control unit, modifying the electrical stimulation signal when the waveform of the electrical stimulation signal deviates from the preset waveform.