# US 10,765,850 B2 · Methods and systems for trans-tissue substance delivery using plasmaporation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,765,850 B2 - Document ID: US10765850B2 - Status: Granted - Kind: B2 - Application number: 15/592,568 - Filed: 2017-05-11 - Published: 2017-11-16 - Granted: 2020-09-08 - Earliest claimed: 2016-05-12 - Assignees: GOJO Industries, Inc. - Applicants: GOJO Industries, Inc. - Inventors: Sameer Kalghatgi; Abhishek Juluri; Jeffrey S. Louis; Tsung-Chan Tsai - Web page: https://patentgrep.com/patent/US10765850B2 ## CPC - A61M 37/0015: {by using microneedles} - A61B 18/042: {using additional gas becoming plasma} - A61K 9/0021: {Intradermal administration, e.g. through microneedle arrays or needleless injectors} - A61N 1/327: {for enhancing the absorption properties of tissue, e.g. by electroporation} - A61N 1/44: Applying ionised fluids {(ion generators H01J37/00)} - A61K 9/7084: {Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches} - A61M 2037/0007: {having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents} - A61M 2037/0023: {Drug applicators using microneedles} - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Exemplary systems and methods associated with trans-tissue substance delivery using non-thermal plasma to porate skin or tissues using contoured dielectrics/electrodes and grounding techniques. In some embodiments, a substance delivery system may be incorporated into the plasma generating device for automatically controlled skin treatments. In other embodiments, a skin treatment patch may include the electrode and the treatment substance. ## Claims ### Claim 1 An apparatus for providing a substance associated with a skin treatment, comprising: a treatment patch applied to skin associated with the skin treatment, wherein the treatment patch comprises: a substrate that flexibly conforms to a shape of the skin; and a substance reservoir for holding a treatment substance associated with the skin treatment; and a plasma generating device for generating a plasma; a power supply for powering the plasma generating device; and first circuitry for providing one or more electrical pulses to the plasma generating device; wherein the plasma generating device and the treatment patch are configured to apply the plasma and the treatment substance to the skin during the skin treatment. ### Claim 2 (depends on 1) The apparatus of claim 1, wherein the treatment substance is applied to the skin through a hole in a high voltage electrode for creating the plasma above the skin. ### Claim 3 (depends on 1) The apparatus of claim 1, wherein the treatment substance is applied to the skin through a hole in a dielectric barrier for preventing a high voltage electrode of the plasma generating device from contacting the skin. ### Claim 4 (depends on 1) The apparatus of claim 1, wherein the treatment patch further comprises microneedles. ### Claim 5 (depends on 1) The apparatus of claim 1, wherein the treatment patch further comprises a high voltage electrode for creating the plasma above the skin. ### Claim 6 (depends on 1) The apparatus of claim 1, wherein the treatment patch further comprises at least one spacer for providing a gap between a dielectric barrier for preventing a high voltage electrode of the plasma generating device from contacting the skin and the skin surface. ### Claim 7 (depends on 1) The apparatus of claim 1, wherein the treatment patch further comprises a dielectric barrier for preventing a high voltage electrode of the plasma generating device from contacting the skin. ### Claim 8 (depends on 7) The apparatus of claim 7, wherein the dielectric barrier is configured to expose the treatment substance to the skin when the dielectric barrier is removed from the treatment patch. ### Claim 9 (depends on 1) The apparatus of claim 1, wherein the treatment patch further comprises a high voltage electrode for creating the plasma above the skin, a dielectric barrier for preventing the high voltage electrode of the plasma generating device from contacting the skin, and at least one spacer for providing a gap between the dielectric barrier and the skin surface, and wherein the treatment patch is configured such that removing at least one of the dielectric barrier and the at least one spacer from the treatment patch exposes the treatment substance to the skin. ### Claim 10 (depends on 1) The apparatus of claim 1, wherein the substance reservoir is between the substrate and a dielectric barrier for preventing a high voltage electrode of the plasma generating device from contacting the skin. ### Claim 11 (depends on 1) The apparatus of claim 1, wherein the treatment patch comprises at least one connection to an electrical circuit. ### Claim 12 (depends on 11) The apparatus of claim 11, wherein the electrical circuit comprises a grounding path. ### Claim 13 (depends on 1) The apparatus of claim 1, wherein the substance reservoir provides the treatment substance to the skin during the skin treatment. ### Claim 14 (depends on 1) The apparatus of claim 1, wherein the plasma generating device comprises a non-thermal DBD plasma generator. ### Claim 15 (depends on 1) The apparatus of claim 1, wherein the plasma generating device and the treatment patch are configured to apply the plasma to the skin before the treatment substance during the skin treatment. ### Claim 16 An apparatus for providing a skin treatment, comprising: a plasma generating device for generating a plasma; a power supply for powering the plasma generating device; and a treatment patch applied to skin associated with the skin treatment, wherein the treatment patch comprises a substrate that flexibly conforms to a shape of the skin, and wherein the treatment patch provides a treatment substance to the skin during the skin treatment; wherein the plasma generating device and the treatment patch are configured to apply the plasma and the treatment substance to the skin during the skin treatment. ### Claim 17 (depends on 15) The apparatus of claim 15, wherein the treatment patch comprises a connection to a grounding circuit. ### Claim 18 (depends on 15) The apparatus of claim 15, wherein the plasma generating device comprises a non-thermal DBD plasma generator.