# US 10,765,829 B2 · Delivery of gases to the nasal airway > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,765,829 B2 - Document ID: US10765829B2 - Status: Granted - Kind: B2 - Application number: 15/869,284 - Filed: 2018-01-12 - Published: 2019-01-17 - Granted: 2020-09-08 - Earliest claimed: 2006-07-25 - Assignees: OptiNose AS - Applicants: OptiNose AS - Inventors: Per Gisle Djupesland; Roderick Peter Hafner - Web page: https://patentgrep.com/patent/US10765829B2 ## CPC - A61M 16/0672: {Nasal cannula assemblies for oxygen therapy} - A61M 15/0003: {with means for dispensing more than one drug} - A61M 15/0028: {using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up} - A61M 15/0065: {Inhalators with dosage or measuring devices (A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52)} - A61M 15/0098: {Activated by exhalation} - A61M 15/08: Inhaling devices inserted into the nose - A61M 16/0003: {Accessories therefor, e.g. sensors, vibrators, negative pressure} - A61M 16/0057: {Pumps therefor} - A61M 16/101: {using an oxygen concentrator} - A61M 16/122: {with dilution} - A61M 16/142: {with semi-permeable walls separating the liquid from the respiratory gas} - A61M 16/22: Carbon dioxide-absorbing devices {; Other means for removing carbon dioxide}(cartridges with absorbing substances for respiratory apparatus A62B19/00) - A61M 15/025: {Bubble jet droplet ejection devices} - A61M 16/0808: {Condensation traps} - A61M 2016/0021: {with a proportional output signal, e.g. from a thermistor} - A61M 2016/0027: {pressure meter} - A61M 2016/003: {with a flowmeter} - A61M 2016/0042: {in the expiratory circuit} - A61M 2202/0208: Oxygen - A61M 2202/0225: Carbon oxides, e.g. Carbon dioxide - A61M 2202/025: Helium - A61M 2202/0266: Nitrogen (N) - A61M 2202/0275: Nitric oxide [NO] - A61M 2202/064: Powder - A61M 2205/3334: Measuring or controlling the flow rate - A61M 2210/0625: Mouth - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A delivery device for and a method of delivering gases to the nasal airway, in particular therapeutic gases and gases in combination with active substances, either as powders or liquids, for enhanced uptake of the active substances. ## Claims ### Claim 1 A method of delivering an uptake enhancing gas and a substance to a nasal airway of a subject comprising: fitting a nosepiece into one nostril of the subject; fitting a mouthpiece into a mouth of the subject, the mouthpiece fluidly connected to the nosepiece and configured to permit the subject to cause a flow of exhaled breath through the mouthpiece and through the nosepiece; causing the substance to be delivered into the flow of exhaled breath; and causing the uptake enhancing gas to be delivered into the flow of exhaled breath; wherein the uptake enhancing gas is carbon dioxide. ### Claim 2 (depends on 1) The method of claim 1, wherein the substance is delivered into the flow of exhaled breath from a container. ### Claim 3 (depends on 2) The method of claim 2, wherein the container is a capsule. ### Claim 4 (depends on 1) The method of claim 1, wherein the substance is a powder. ### Claim 5 (depends on 1) The method of claim 1, wherein the substance is a liquid. ### Claim 6 (depends on 1) The method of claim 1, wherein the substance is an aerosol. ### Claim 7 (depends on 1) The method of claim 1, further comprising causing a concentration of a gas within the flow of exhaled breath to be reduced. ### Claim 8 (depends on 1) The method of claim 1, further comprising causing a concentration of a gas within the flow of exhaled breath to be increased. ### Claim 9 (depends on 1) The method of claim 1, further comprising causing an amount of a first gas to be added into the flow of exhaled breath. ### Claim 10 (depends on 9) The method of claim 9, wherein the first gas is a gas that is not present in the flow of exhaled breath. ### Claim 11 A method of delivering an uptake enhancing gas and a substance to a nasal airway of a subject comprising: fitting a nosepiece into one nostril of the subject; fitting a mouthpiece into a mouth of the subject, the mouthpiece fluidly connected to the nosepiece and configured to permit the subject to cause a flow of exhaled breath through the mouthpiece and through the nosepiece; and causing the substance and the uptake enhancing gas to be delivered into the flow of exhaled breath; wherein the uptake enhancing gas is at least 10 vol. % of a combined flow of the flow of exhaled breath and the uptake enhancing gas. ### Claim 12 (depends on 11) The method of claim 11, wherein the substance is delivered into the flow of exhaled breath from a container. ### Claim 13 (depends on 12) The method of claim 12, wherein the container is a capsule. ### Claim 14 (depends on 11) The method of claim 11, wherein the substance is a powder. ### Claim 15 (depends on 11) The method of claim 11, wherein the substance is a liquid. ### Claim 16 (depends on 11) The method of claim 11, wherein the substance is an aerosol. ### Claim 17 (depends on 11) The method of claim 11, wherein the uptake enhancing gas is carbon dioxide. ### Claim 18 (depends on 11) The method of claim 11, wherein the uptake enhancing gas is nitric oxide. ### Claim 19 (depends on 11) The method of claim 11, wherein the uptake enhancing gas is oxygen. ### Claim 20 (depends on 11) The method of claim 11, wherein the uptake enhancing gas is helium. ### Claim 21 (depends on 11) The method of claim 11, further comprising causing a concentration of a gas within the flow of exhaled breath to be reduced. ### Claim 22 (depends on 11) The method of claim 11, further comprising causing a concentration of a gas within the flow of exhaled breath to be increased. ### Claim 23 (depends on 11) The method of claim 11, further comprising causing an amount of a first gas to be added into the flow of exhaled breath. ### Claim 24 (depends on 23) The method of claim 23, wherein the first gas is a gas that is not present in the flow of exhaled breath.