# US 10,765,811 B2 · Versatile syringe platform

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,765,811 B2
- Document ID: US10765811B2
- Status: Granted
- Kind: B2
- Application number: 14/962,554
- Filed: 2015-12-08
- Published: 2016-11-10
- Granted: 2020-09-08
- Earliest claimed: 2014-12-08
- Assignees: Genentech, Inc.
- Applicants: Genentech, Inc.
- Inventors: Lionel Vedrine; Steven N. Roe; Mukund Patel
- Web page: https://patentgrep.com/patent/US10765811B2

## CPC

- A61M 5/31513: {Piston constructions to improve sealing or sliding}
- A61F 9/0017: {implantable in, or in contact with, the eye, e.g. ocular inserts}
- A61M 5/24: Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
- A61M 5/2448: {comprising means for injection of two or more media, e.g. by mixing}
- A61M 5/2459: {upon internal pressure increase, e.g. pierced or burst (A61M5/2429 takes precedence)}
- A61M 5/3137: {with finger grip means, e.g. for easy manipulation of the syringe rod}
- A61M 5/3145: {Filters incorporated in syringes}
- A61M 5/3146: {Priming, e.g. purging, reducing backlash or clearance}
- A61M 5/31505: {Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit}
- A61M 5/31528: {by means of rotational movements, e.g. screw-thread mechanisms}
- A61M 5/3157: {Means providing feedback signals when administration is completed (A61M5/20 takes precedence)}
- A61M 5/31573: {Accuracy improving means}
- A61M 5/31581: {the component being manually operated or triggered by a rotating or pivoting actuator operated by user, e.g. an injection lever or handle}
- A61M 5/31586: {the component being manually operated or triggered by a rotating or pivoting actuator operated by user, e.g. an injection lever or handle}
- A61M 5/31596: {comprising means for injection of two or more media, e.g. by mixing}
- A61M 5/3202: {Devices for protection of the needle before use, e.g. caps (A61M5/50 takes precedence; protectors for sharps A61B50/3001)}
- A61M 5/3298: {Needles arranged in parallel}
- A61M 5/36: with means for eliminating or preventing injection or infusion of air into body (dialysis systems, blood oxygenators A61M1/14; haemofiltration equipment A61M1/34; {automatic tube cut-off A61M39/281})
- A61M 5/2033: {Spring-loaded one-shot injectors with or without automatic needle insertion (multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287)}
- A61M 5/284: {comprising means for injection of two or more media, e.g. by mixing}
- A61M 2005/2451: {preventing delivery before mixing is completed, e.g. by locking mechanisms}
- A61M 2005/31508: {provided on the piston-rod}
- A61M 2205/581: by audible feedback
- A61M 2205/582: by tactile feedback
- A61M 2205/583: by visual feedback
- A61M 2207/00: Methods of manufacture, assembly or production
- B29C 45/16: Making multilayered or multicoloured articles {(B29C45/0062 takes precedence; feeding colouring materials into the injection unit B29C45/1816)}
- B29L 2031/7544: {Injection needles, syringes}
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- B29C: SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING (making preforms B29B11/00; making laminated products by combining previously unconnected layers which become one product whose layers will remain together B32B37/00 - B32B41/00)
- B29L: INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES

## Abstract

Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.

## Claims

### Claim 1

A medicament delivery device defining a longitudinal axis and having a distal end, the device comprising:
a collar disposed coaxial with the longitudinal axis and supporting a flexible panel and a projection; and
a plunger rod that is threadingly engaged, coaxially within the collar, with a proximal knob having a track that supports a trigger;
wherein:
the flexible panel:
is configured, responsive to interaction with the trigger, to move in deflection relative to the longitudinal axis; and
slidingly engages the track to longitudinally retain the knob during a rotation of the knob about the longitudinal axis;
the projection slidingly engages a longitudinally extending structure of the plunger rod to rotationally retain the plunger rod during the rotation, the rotation driving the plunger rod toward the distal end;
the longitudinally extending structure:
extends along a length that is disposed between a proximal thread of the plunger rod and a distal end of the plunger rod; and
supports a surface feature configured to interfere with the projection to longitudinally retain the plunger rod from proximal movement; and
the projection:
projects radially inward;
has a distal stop surface that provides blockage against distal movement of the projection relative to the surface feature; and
proximal to the distal stop surface, provides passage for proximal movement of the projection relative to the surface feature.

### Claim 2 (depends on 1)

The device of claim 1 wherein:
the track includes an annular tract and a longitudinal tract, the annular tract intersecting the longitudinal tract, the flexible panel slidingly engaging:
the annular tract during the rotation; and
the longitudinal tract during a longitudinal translation of the knob;
the longitudinal tract retains the knob rotationally during the translation and corresponds, in longitudinal extent from the intersecting, to a target amount of medicament;
the translation is delimited by interference between the flexible panel and a proximal terminal surface of the longitudinal tract; and
the interference:
limits motion of the flexible panel, relative to the knob, to motion that is directed away from the terminal surface and parallel to the longitudinal axis; and
terminates advancement of medicament out of the distal end.

### Claim 3 (depends on 2)

The device of claim 2 wherein:
the collar further supports a bracket configured to retain, coaxially with the knob, a medicament container;
the container defines a bore bound by an interior sidewall that defines, along a segment of the sidewall, a uniform diameter,
a distal end of the plunger rod abuts a plunger within the container, the plunger being slidingly engaged with the sidewall;
before the translation, the plunger seals a pre-delivery amount of the medicament between an inner distal shoulder of the container and the plunger; and,
after the translation, a distal portion of the segment contacts a bulk liquid residuum contained between the inner distal shoulder and the plunger.

### Claim 4 (depends on 3)

The device of claim 3 wherein an amount of the medicament in the residuum is no greater than the pre-delivery amount less the target amount.

### Claim 5 (depends on 3)

The device of claim 3 wherein the distal portion of the segment directly contacts the residuum.

### Claim 6 (depends on 3)

The device of claim 3 wherein the rotation sets the pre-delivery amount between the inner distal shoulder of the container and the plunger, the rotation preparing the medicament for delivery.

### Claim 7 (depends on 6)

The device of claim 6 wherein the preparing comprises mixing components of the medicament within the container.

### Claim 8 (depends on 6)

The device of claim 6 wherein the preparing comprises priming the container.

### Claim 9 (depends on 8)

The device of claim 8 wherein the priming comprises distal discharge of air from the container.

### Claim 10 (depends on 2)

The device of claim 2 wherein the knob further has signage providing indication of a stage of device operation and the collar defines a window exposing a portion of the signage, the portion indicating:
prior to the rotation, a medicament preparation stage of the device operation; and
after the rotation, a medicament delivery stage of the device operation.

### Claim 11 (depends on 10)

The device of claim 10 wherein the portion indicates, during the rotation, continuation of the preparation stage.

### Claim 12 (depends on 10)

The device of claim 10 wherein the portion indicates:
after the rotation and prior to the translation, commencement of the delivery stage; and
after the translation, completion of the delivery stage.

### Claim 13 (depends on 1)

The device of claim 1 wherein:
the surface feature has a proximal stop surface that provides blockage against distal movement of the projection relative to the surface feature; and,
distal to the proximal stop surface, the surface feature provides passage for proximal movement of the projection relative to the surface feature.

### Claim 14 (depends on 1)

The device of claim 1 wherein the longitudinally extending structure:
is a slot that extends radially inward; and
the surface feature extends, in a plane transverse to the longitudinal axis, into the slot.

### Claim 15 (depends on 1)

The device of claim 1 wherein the longitudinally extending structure:
is a rail that extends radially outward; and
the surface feature extends, in a plane transverse to the longitudinal axis, out from the rail.

### Claim 16

A medicament delivery device defining a longitudinal axis and having a distal end, the device comprising:
a collar disposed coaxial with the longitudinal axis and supporting a flexible panel and a projection; and
a plunger rod that is threadingly engaged, coaxially within the collar, with a proximal knob having a track that supports a trigger;
wherein:
the flexible panel:
is configured, responsive to interaction with the trigger, to move in deflection relative to the longitudinal axis; and
slidingly engages the track to longitudinally retain the knob during a rotation of the knob about the longitudinal axis;
the projection slidingly engages a longitudinally extending structure of the plunger rod to rotationally retain the plunger rod during the rotation, the rotation driving the plunger rod toward the distal end;
the track includes an annular tract and a longitudinal tract, the annular tract intersecting the longitudinal tract, the flexible panel slidingly engaging:
the annular tract during the rotation; and
the longitudinal tract during a longitudinal translation of the knob;
the longitudinal tract retains the knob rotationally during the translation and corresponds, in longitudinal extent from the intersecting, to a target amount of medicament;
the translation is delimited by interference between the flexible panel and a proximal terminal surface of the longitudinal tract; and
the interference:
limits motion of the flexible panel, relative to the knob, to motion that is directed away from the terminal surface and parallel to the longitudinal axis; and
terminates advancement of medicament out of the distal end;
the flexible panel is supported by a boss that is supported by the collar; and,
in the rotation:
the boss is in sliding engagement with the annular tract; and
the flexible panel trails all other surfaces of the boss.

### Claim 17 (depends on 16)

The device of claim 16 wherein the flexible panel includes a free end that is disposed more radially inward than any other surface of the flexible panel.

### Claim 18 (depends on 17)

The device of claim 17 wherein, in the rotation, the free end trails all other surfaces of the flexible panel.

### Claim 19 (depends on 17)

The device of claim 17 wherein a running surface of the track supports the trigger, the free end interacting with the trigger, to produce the deflection, when the flexible panel passes by the trigger.

### Claim 20 (depends on 19)

The device of claim 19 wherein the interaction occurs upon initiation of the rotation.

### Claim 21 (depends on 20)

The device of claim 20 wherein, prior to the interaction:
the boss is disposed adjacent a portion of the annular tract that is circumferentially most distant, in the direction of the rotation, from the longitudinal tract; and
the trigger limits motion of the free end along the track.

### Claim 22 (depends on 19)

The device of claim 19 wherein the interaction occurs upon completion of the rotation.

### Claim 23 (depends on 22)

The device of claim 22 wherein the trigger:
is disposed on the annular tract at a juncture of the annular tract and the longitudinal tract; and
following the interaction, limits rotary motion of the knob in a direction opposite the rotation.

### Claim 24 (depends on 23)

The device of claim 23 wherein, following the interaction, the flexible panel is circumferentially aligned with the longitudinal tract.

### Claim 25 (depends on 19)

The device of claim 19 wherein the deflection provides indication of the interaction.

### Claim 26 (depends on 25)

The device of claim 25 wherein the indication is tactile.

### Claim 27 (depends on 25)

The device of claim 25 wherein the indication is acoustic.

### Claim 28 (depends on 17)

The device of claim 17 wherein the trigger has a stop surface configured to block passage of the free end in a direction opposite to the rotation.

### Claim 29 (depends on 28)

The device of claim 28 wherein:
the trigger is a protrusion;
the interaction is an interference between the free end and the trigger; and,
during the rotation, the flexible panel passes by the stop surface after passing by all other surfaces of the trigger.

### Claim 30 (depends on 28)

The device of claim 28 wherein:
the trigger is a recess;
the interaction is an urging of the free end against the recess; and,
during the rotation, the flexible panel passes by the stop surface before passing by any other surface of the trigger.

### Claim 31 (depends on 16)

The device of claim 16 wherein:
the rotation is delimited by abutment of the boss against a lateral surface of the longitudinal tract; and
the abutment circumferentially aligns the boss with the longitudinal tract.

### Claim 32 (depends on 31)

The device of claim 31 wherein the abutment provides tactile indication of completion of a medicament preparation stage of device operation.

### Claim 33 (depends on 31)

The device of claim 31 wherein the abutment provides acoustic indication of completion of a medicament preparation stage of device operation.

### Claim 34 (depends on 16)

The device of claim 16 wherein the interference provides indication of completion of a medicament delivery stage of device operation.

### Claim 35

A medicament delivery device for delivering a target amount of medicament from a distal end of the device, the device defining a longitudinal axis and comprising:
a collar disposed coaxial with the longitudinal axis and having a boss and a projection; and
a plunger rod that is threadingly engaged, coaxially within the collar, with a proximal knob having a track, the track including an annular tract and a longitudinal tract;
wherein:
the boss slidingly engages:
the annular tract to longitudinally retain the knob during a rotation of the knob about the longitudinal axis; and,
after the rotation of the knob, the longitudinal tract during a longitudinal translation of the knob;
the projection slidingly engages a longitudinally extending structure of the plunger rod to rotationally retain the plunger rod during the rotation, the rotation driving the plunger rod toward the distal end; and
the translation advances the target amount out of the distal end.

### Claim 36 (depends on 35)

The device of claim 35 wherein:
the longitudinal tract intersects the annular tract;
the rotation is delimited by abutment of the boss against a lateral surface of the longitudinal tract;
the translation is delimited by interference between the boss and a proximal terminal surface of the longitudinal tract;
the longitudinal tract retains the knob rotationally during the translation and corresponds, in longitudinal extent from a location of the abutment, to the target amount; and
the interference:
limits motion of the boss, relative to the knob, to motion that is directed away from the terminal surface and parallel to the longitudinal axis; and
terminates advancement of medicament out of the distal end.

### Claim 37 (depends on 36)

The device of claim 36 wherein the abutment provides tactile indication of completion of a medicament preparation stage of device operation.

### Claim 38 (depends on 36)

The device of claim 36 wherein the abutment provides acoustic indication of completion of a medicament preparation stage of device operation.

### Claim 39 (depends on 36)

The device of claim 36 wherein the interference provides indication of completion of a medicament delivery stage of device operation.

### Claim 40 (depends on 35)

The device of claim 35 wherein:
the collar further has a bracket configured to retain, coaxially with the knob, a medicament container;
the container defines a bore bound by an interior sidewall that defines, along a segment of the sidewall, a uniform diameter,
a distal end of the plunger rod abuts a plunger within the container, the plunger being slidingly engaged with the sidewall;
before the translation, the plunger seals a pre-delivery amount of the medicament between an inner distal shoulder of the container and the plunger; and,
after the translation, a distal portion of the segment contacts a bulk liquid residuum contained between the inner distal shoulder and the plunger, an amount of the medicament in the residuum being no greater than the pre-delivery amount less the target amount.

### Claim 41 (depends on 40)

The device of claim 40 wherein the rotation sets the pre-delivery amount between the inner distal shoulder of the container and the plunger, the rotation preparing the medicament for delivery.

### Claim 42 (depends on 41)

The device of claim 41 wherein the preparing comprises mixing components of the medicament within the container.

### Claim 43 (depends on 41)

The device of claim 41 wherein the preparing comprises priming the container.

### Claim 44 (depends on 43)

The device of claim 43 wherein the priming comprises distal discharge of air from the container.

### Claim 45 (depends on 35)

The device of claim 35 wherein the knob further has signage providing indication of a stage of device operation and the collar defines a window exposing a portion of the signage, the portion indicating:
prior to the rotation, a medicament preparation stage of the device operation;
during the rotation, continuation of the preparation stage; and,
after the rotation, a medicament delivery stage of the device operation.

### Claim 46 (depends on 45)

The device of claim 45 wherein the portion indicates:
after the rotation and prior to the translation, commencement of the delivery stage; and
after the translation, completion of the delivery stage.

### Claim 47 (depends on 35)

The device of claim 35 wherein the longitudinally extending structure:
extends along a length that is disposed between a proximal thread of the plunger rod and a distal end of the plunger rod; and
supports a surface feature configured to interfere with the projection to longitudinally retain the plunger rod from proximal movement.

### Claim 48 (depends on 47)

The device of claim 47, wherein:
the surface feature has a proximal stop surface that provides blockage against distal movement of the projection relative to the surface feature; and,
distal to the proximal stop surface, the surface feature provides passage for proximal movement of the projection relative to the surface feature.

### Claim 49 (depends on 47)

The device of claim 47 wherein the projection:
projects radially inward; and
has a distal stop surface that provides blockage against distal movement of the projection relative to the surface feature;
wherein, proximal to the distal stop surface, the projection provides passage for proximal movement of the projection relative to the surface feature.

### Claim 50 (depends on 47)

The device of claim 47 wherein the longitudinally extending structure:
is a slot that extends radially inward; and
the surface feature extends, in a plane transverse to the longitudinal axis, into the slot.

### Claim 51 (depends on 47)

The device of claim 47 wherein the longitudinally extending structure:
is a rail that extends radially outward; and
the surface feature extends, in a plane transverse to the longitudinal axis, out from the rail.

### Claim 52 (depends on 35)

The device of claim 35 wherein the boss includes a flexible panel that has a free end that is disposed more radially inward than any other surface of the boss.

### Claim 53 (depends on 52)

The device of claim 52 wherein a running surface of the track supports a trigger, the free end being configured, responsive to interaction between the free end and the trigger, to move in deflection relative to the longitudinal axis when the flexible panel passes by the trigger.

### Claim 54 (depends on 53)

The device of claim 53 wherein the interaction occurs upon initiation of the rotation.

### Claim 55 (depends on 54)

The device of claim 54 wherein, prior to the interaction:
the boss is disposed adjacent a portion of the annular tract that is circumferentially most distant, in the direction of the rotation, from the longitudinal tract; and
the trigger limits motion of the free end along the track.

### Claim 56 (depends on 53)

The device of claim 53 wherein the interaction occurs upon completion of the rotation.

### Claim 57 (depends on 56)

The device of claim 56 wherein the trigger:
is disposed on the annular tract at a juncture of the annular tract and the longitudinal tract; and
following the interaction, limits rotary motion of the knob in a direction opposite the rotation.

### Claim 58 (depends on 53)

The device of claim 53 wherein the deflection provides indication of the interaction.

### Claim 59 (depends on 58)

The device of claim 58 wherein the indication is tactile.

### Claim 60 (depends on 58)

The device of claim 58 wherein the indication is acoustic.

### Claim 61 (depends on 52)

The device of claim 52 wherein the trigger has a trigger stop surface configured to block passage of the free end in a direction opposite to the rotation.

### Claim 62 (depends on 61)

The device of claim 61 wherein:
the trigger is a protrusion;
the interaction is an interference between the free end and the trigger; and,
during the rotation, the flexible panel passes by the trigger stop surface after passing by all other surfaces of the trigger.

### Claim 63 (depends on 61)

The device of claim 61 wherein:
the trigger is a recess;
the interaction is an urging of the free end against the recess; and,
during the rotation, the flexible panel passes by the trigger stop surface before passing by any other surface of the trigger.

### Claim 64

A method of manufacturing a medicament delivery device, the method comprising:
providing a knob having an annular recess that includes a surface from which extends a protrusion;
providing a collar that supports a flexible panel that extends into an interior of the collar;
positioning the knob coaxially within the collar so that a free end of the flexible panel extends radially inward beyond the protrusion and is deflectable by the protrusion when the knob rotates relative to the collar;
threadingly engaging a plunger rod with the knob; and
securing the plunger rod against rotation relative to the knob.

### Claim 65 (depends on 64)

The method of claim 64 wherein the providing a knob comprises providing a knob that has a longitudinal recess that:
intersects the annular recess; and
supports a terminal surface configured to abut the flexible panel.

### Claim 66 (depends on 64)

The method of claim 64 wherein:
the providing a collar comprises providing a collar that includes a projection; and
the securing includes engaging the projection with a longitudinally extending structure of the plunger rod.

### Claim 67 (depends on 66)

The method of claim 66 wherein:
the longitudinally extending structure includes a slot; and
the engaging includes insertion of the projection into the slot.

### Claim 68 (depends on 66)

The method of claim 66 wherein:
the longitudinally extending structure includes a rail; and
the engaging includes positioning the projection alongside the rail.

### Claim 69 (depends on 64)

The method of claim 64 further comprising providing the plunger rod, wherein the plunger rod includes an end supporting a thread engageable with the knob.

### Claim 70

A medicament delivery device for delivering a target amount of medicament from a distal end of the device, the device defining a longitudinal axis and comprising:
a collar disposed coaxial with the longitudinal axis and having a boss and a projection; and
a plunger rod that is threadingly engaged, coaxially within the collar, with a proximal knob having a track, the track including an annular tract and a longitudinal tract;
wherein:
the boss slidingly engages:
the annular tract to longitudinally retain the knob during a rotation of the knob about the longitudinal axis; and
the longitudinal tract during a longitudinal translation of the knob;
the projection slidingly engages a longitudinally extending structure of the plunger rod to rotationally retain the plunger rod during the rotation, the rotation driving the plunger rod toward the distal end;
the translation:
is delimited by interference between the boss and a proximal terminal surface of the longitudinal tract; and
advances the target amount out of the distal end;
the longitudinally extending structure:
extends along a length that is disposed between a proximal thread of the plunger rod and a distal end of the plunger rod; and
supports a surface feature configured to interfere with the projection to longitudinally retain the plunger rod from proximal movement; and
the projection:
projects radially inward;
has a distal stop surface that provides blockage against distal movement of the projection relative to the surface feature; and
proximal to the distal stop surface, provides passage for proximal movement of the projection relative to the surface feature.

### Claim 71 (depends on 70)

The device of claim 70 wherein:
the longitudinal tract intersects the annular tract;
the rotation is delimited by abutment of the boss against a lateral surface of the longitudinal tract;
the longitudinal tract retains the knob rotationally during the translation and corresponds, in longitudinal extent from a location of the abutment, to the target amount; and
the interference:
limits motion of the boss, relative to the knob, to motion that is directed away from the terminal surface and parallel to the longitudinal axis; and
terminates advancement of medicament out of the distal end.

### Claim 72 (depends on 71)

The device of claim 71 wherein the abutment provides tactile indication of completion of a medicament preparation stage of device operation.

### Claim 73 (depends on 71)

The device of claim 71 wherein the abutment provides acoustic indication of completion of a medicament preparation stage of device operation.

### Claim 74 (depends on 71)

The device of claim 71 wherein the interference provides indication of completion of a medicament delivery stage of device operation.

### Claim 75 (depends on 70)

The device of claim 70 wherein:
the collar further has a bracket configured to retain, coaxially with the knob, a medicament container;
the container defines a bore bound by an interior sidewall that defines, along a segment of the sidewall, a uniform diameter,
a distal end of the plunger rod abuts a plunger within the container, the plunger being slidingly engaged with the sidewall;
before the translation, the plunger seals a pre-delivery amount of the medicament between an inner distal shoulder of the container and the plunger; and,
after the translation, a distal portion of the segment contacts a bulk liquid residuum contained between the inner distal shoulder and the plunger, an amount of the medicament in the residuum being no greater than the pre-delivery amount less the target amount.

### Claim 76 (depends on 75)

The device of claim 75 wherein the rotation sets the pre-delivery amount between the inner distal shoulder of the container and the plunger, the rotation preparing the medicament for delivery.

### Claim 77 (depends on 76)

The device of claim 76 wherein the preparing comprises mixing components of the medicament within the container.

### Claim 78 (depends on 76)

The device of claim 76 wherein the preparing comprises priming the container.

### Claim 79 (depends on 78)

The device of claim 78 wherein the priming comprises distal discharge of air from the container.

### Claim 80 (depends on 70)

The device of claim 70 wherein the knob further has signage providing indication of a stage of device operation and the collar defines a window exposing a portion of the signage, the portion indicating:
prior to the rotation, a medicament preparation stage of the device operation;
during the rotation, continuation of the preparation stage; and,
after the rotation, a medicament delivery stage of the device operation.

### Claim 81 (depends on 80)

The device of claim 80 wherein the portion indicates:
after the rotation and prior to the translation, commencement of the delivery stage; and
after the translation, completion of the delivery stage.

### Claim 82 (depends on 70)

The device of claim 70 wherein:
the surface feature has a proximal stop surface that provides blockage against distal movement of the projection relative to the surface feature; and,
distal to the proximal stop surface, the surface feature provides passage for proximal movement of the projection relative to the surface feature.

### Claim 83 (depends on 70)

The device of claim 70 wherein the longitudinally extending structure:
is a slot that extends radially inward; and
the surface feature extends, in a plane transverse to the longitudinal axis, into the slot.

### Claim 84 (depends on 70)

The device of claim 70 wherein the longitudinally extending structure:
is a rail that extends radially outward; and
the surface feature extends, in a plane transverse to the longitudinal axis, out from the rail.

### Claim 85 (depends on 70)

The device of claim 70 wherein the boss includes a flexible panel that has a free end that is disposed more radially inward than any other surface of the boss.

### Claim 86 (depends on 85)

The device of claim 85 wherein a running surface of the track supports a trigger, the free end being configured, responsive to interaction between the free end and the trigger, to move in deflection relative to the longitudinal axis when the flexible panel passes by the trigger.

### Claim 87 (depends on 86)

The device of claim 86 wherein the interaction occurs upon initiation of the rotation.

### Claim 88 (depends on 87)

The device of claim 87 wherein, prior to the interaction:
the boss is disposed adjacent a portion of the annular tract that is circumferentially most distant, in the direction of the rotation, from the longitudinal tract; and
the trigger limits motion of the free end along the track.

### Claim 89 (depends on 86)

The device of claim 86 wherein the interaction occurs upon completion of the rotation.

### Claim 90 (depends on 89)

The device of claim 89 wherein the trigger:
is disposed on the annular tract at a juncture of the annular tract and the longitudinal tract; and
following the interaction, limits rotary motion of the knob in a direction opposite the rotation.

### Claim 91 (depends on 86)

The device of claim 86 wherein the deflection provides indication of the interaction.

### Claim 92 (depends on 91)

The device of claim 91 wherein the indication is tactile.

### Claim 93 (depends on 91)

The device of claim 91 wherein the indication is acoustic.

### Claim 94 (depends on 85)

The device of claim 85 wherein the trigger has a trigger stop surface configured to block passage of the free end in a direction opposite to the rotation.

### Claim 95 (depends on 94)

The device of claim 94 wherein:
the trigger is a protrusion;
the interaction is an interference between the free end and the trigger; and,
during the rotation, the flexible panel passes by the trigger stop surface after passing by all other surfaces of the trigger.

### Claim 96 (depends on 94)

The device of claim 94 wherein:
the trigger is a recess;
the interaction is an urging of the free end against the recess; and,
during the rotation, the flexible panel passes by the trigger stop surface before passing by any other surface of the trigger.

### Claim 97

A medicament delivery device for delivering a target amount of medicament from a distal end of the device, the device defining a longitudinal axis and comprising:
a collar disposed coaxial with the longitudinal axis and having a boss and a projection; and
a plunger rod that is threadingly engaged, coaxially within the collar, with a proximal knob having a track, the track including an annular tract and a longitudinal tract;
wherein:
the boss slidingly engages:
the annular tract to longitudinally retain the knob during a rotation of the knob about the longitudinal axis; and
the longitudinal tract during a longitudinal translation of the knob;
the projection slidingly engages a longitudinally extending structure of the plunger rod to rotationally retain the plunger rod during the rotation, the rotation driving the plunger rod toward the distal end; and,
in the translation, the knob carries the threadingly engaged plunger rod distally forward.

### Claim 98 (depends on 97)

The device of claim 97 wherein the plunger rod moving distally forward advances the target amount out of the distal end.