# US 10,765,725 B2 · Methods for treatment of surgery associated pain

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- Number: US 10,765,725 B2
- Document ID: US10765725B2
- Status: Granted
- Kind: B2
- Application number: 16/180,085
- Filed: 2018-11-05
- Published: 2019-02-21
- Granted: 2020-09-08
- Earliest claimed: 2015-12-03
- Assignees: Children's Hospital Medical Center
- Applicants: Children's Hospital Medical Center
- Inventors: Michael P. Jankowski; Xiaohua Liu; John Barns Rose
- Web page: https://patentgrep.com/patent/US10765725B2

## CPC

- A61K 38/27: Growth hormone [GH], i.e. somatotropin
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Disclosed are methods of treating pain in a mammal, which may include the step of administering human growth hormone to a mammal in need thereof. The pain treated by the disclosed methods may be of a type caused by inflammation induced mechanical and/or thermal hypersensitivity, and may include, for example, a pain type resulting from one or more conditions selected from peripheral injury pain, post-operative pain, cutaneous inflammation, cutaneous incision, muscle incision, or chronic pain. Disease states in which the disclosed methods may be used include fibromyalgia, sickle cell anemia, epidermolysis bullosa, erythromelalgia, complex regional pain syndrome, or generalized muscle pain.

## Claims

### Claim 1

A method of preventing or treating pain in a subject, comprising the step of administering growth hormone to said subject immediately prior, during, or after a surgical event, wherein said administration is to a site of a cutaneous and/or muscular inflammation associated with said surgical event.

### Claim 2 (depends on 1)

The method of claim 1, wherein said growth hormone is administered post-operatively to a site of injury associated with said surgical event.

### Claim 3 (depends on 1)

The method of claim 1, wherein said growth hormone is administered to said subject pre-operatively to said surgical event.

### Claim 4 (depends on 1)

The method of claim 1, wherein said growth hormone is delivered topically.

### Claim 5 (depends on 1)

The method of claim 1 wherein said growth hormone is administered to said subject at a dose of from about 0.1 mg/kg to about 3 mg/kg, or from about 1 mg/kg to about 2 mg/kg.

### Claim 6 (depends on 1)

The method of claim 1 wherein said subject is a neonate, child, juvenile, or young adult.

### Claim 7 (depends on 1)

The method of claim 1 wherein said growth hormone is delivered in a sterile liquid.

### Claim 8 (depends on 7)

The method of claim 7 wherein said sterile liquid is selected from water, saline, or combinations thereof.

### Claim 9 (depends on 1)

The method of claim 1 wherein said growth hormone is delivered in an aqueous carrier.