# US 10,765,712 B2 · Use of a composition for lowering cholesterol level in a mammal, a method for its preparation and a product and a food additive comprising said composition

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- Number: US 10,765,712 B2
- Document ID: US10765712B2
- Status: Granted
- Kind: B2
- Application number: 16/208,597
- Filed: 2018-12-04
- Published: 2019-04-25
- Granted: 2020-09-08
- Earliest claimed: 2015-12-09
- Assignees: Oy Granula Ab Ltd.
- Applicants: Oy Granula Ab Ltd.
- Inventors: Thomas Ahlnäs
- Web page: https://patentgrep.com/patent/US10765712B2

## CPC

- A61K 36/15: Pinaceae (Pine family), e.g. pine or cedar
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A61K 9/08: Solutions {(composition of solutions A61K47/00)}
- A61K 31/05: Phenols {(cannabinoids A61K31/658)}
- A61K 31/09: having two or more such linkages
- A61K 31/34: having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K 31/341: not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
- A61K 31/365: Lactones
- A61K 31/56: Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 2236/33: involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

A method to lower cholesterol level in a mammal blood serum is provided. A composition to lower the cholesterol levels and a method to make the composition is also disclosed. Food products with elongated shelf life as well as beneficial effects on human health are disclosed.

## Claims

### Claim 1

An alcohol-wood extract for lowering cholesterol level of blood serum in a mammal, said extract comprising an extraction solution and a lignan mixture at a range of 1-50 wt-%, the lignan mixture comprising:
70-80 wt-% 7-hydroxymatairesinol, 3-8 wt-% conidendrin, 1-4 wt-% lariciresinol, 2-5 wt-% liovil, 3-7 wt-% secoisolarisinol, and 0-3 wt-% other lignans.

### Claim 2 (depends on 1)

The extract of claim 1, wherein the extract comprises extraction solution from extraction of knot wood wherein the extraction solution is selected from the group consisting of an alcohol and a water-alcohol mixture.

### Claim 3 (depends on 1)

The extract according to claim 1, wherein the extract additionally comprises one or more lignan(s) at a range of 0-10 wt-% selected from the group consisting of pinoresinol, nortrachelogenin, matairesinol, juvabiones, their geometric isomers or stereoisomers, and oligolignans.

### Claim 4 (depends on 2)

The extract according to claim 2, wherein the extraction solution comprises a monovalent lower alcohol and/or, a divalent lower alcohol and/or a trivalent lower alcohol.

### Claim 5 (depends on 1)

The extract according to claim 1, wherein the extract further comprises triterpens or stilbenes selected from the group consisting of betulin, betulonic acid, betulinic acid, betuloinic acid, resveratrol, their geometric isomers and stereoisomers thereof.

### Claim 6 (depends on 1)

The extract according to claim 1, wherein the extract further comprises added vitamin(s) or plant lignan(s).

### Claim 7 (depends on 1)

The extract according to claim 1, wherein the extract comprises 7.5 wt-% of the lignan mixture.