# US 10,765,708 B2 · Formulation and treatment for acne

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- Number: US 10,765,708 B2
- Document ID: US10765708B2
- Status: Granted
- Kind: B2
- Application number: 15/369,660
- Filed: 2016-12-05
- Published: 2017-05-25
- Granted: 2020-09-08
- Earliest claimed: 2011-09-21
- Assignees: JAO Beheer B.V.
- Applicants: JAO Beheer BV
- Inventors: Elzbieta Ewa Brand-Garnys
- Web page: https://patentgrep.com/patent/US10765708B2

## CPC

- A61K 8/4973: {with oxygen as the only hetero atom}
- A61K 8/553: {Phospholipids, e.g. lecithin}
- A61K 8/99: from microorganisms other than algae or fungi, e.g. protozoa or bacteria
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 35/74: Bacteria (therapeutic use of a bacterial protein A61K38/00)
- A61K 35/747: Lactobacilli, e.g. L. acidophilus or L. brevis
- A61K 36/899: Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K 47/08: containing oxygen, {e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides}
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/186: {Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide}
- A61K 47/24: containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
- A61K 47/26: Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A61K 47/38: Cellulose; Derivatives thereof
- A61P 17/10: Anti-acne agents
- A61Q 19/00: Preparations for care of the skin
- A61K 2236/19: involving fermentation using yeast, bacteria or both; enzymatic treatment
- A61K 2800/85: Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
- A61K 2800/874: Roll-on
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present invention relates to composition comprising Lactobacillus rye ferment, dialkylisosorbide and phospholipid. Preferably, the composition further comprises ethoxylated sorbitan fatty acid ester. The composition has been shown to be effective against infections of closed comedones. The invention further relates to a method of preparing the composition, to a roll-on applicator comprising the composition and to the use of the composition in treatment of closed comedones infections.

## Claims

### Claim 1

A method of treating Propionibacterium acnes infected comedones, the method comprising: administering a composition comprising:
from 40 to 65% by weight of Lactobacillus rye ferment;
from 1.2 to 5% by weight of dimethyl isosorbide;
from 0.1 to 0.4% by weight of phosphatidylcholine; and
from 0.2 to 1.5% by weight of polysorbate 80.

### Claim 2 (depends on 1)

The method according to claim 1, the composition further comprising hydroxyethylcellulose and hydroxypropylcellulose, each at a level of from 0.01 to 3% by weight.

### Claim 3 (depends on 1)

The method according to claim 1, the composition further comprising an osmolyte selected from betaines and nonionic osmolytes at a level of from 0.1 to 5% by weight of the composition.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the composition is administered to the infected comedones with a roll-on applicator.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the composition is applied topically.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the Lactobacillus is selected from Lactobacillus DSM 6037, Lactobacillus DSM 6129, and mixtures thereof.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the composition comprises from 40 to 65% by weight of Lactobacillus rye ferment;
3.2% by weight of dimethyl isosorbide;
0.25% by weight of phosphatidylcholine; and
0.35% by weight of polysorbate 80.