# US 10,765,663 B2 · Nutrition composition > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,765,663 B2 - Document ID: US10765663B2 - Status: Granted - Kind: B2 - Application number: 14/834,880 - Filed: 2015-08-25 - Published: 2015-12-17 - Granted: 2020-09-08 - Earliest claimed: 2013-02-26 - Assignees: Ajinomoto Co., Inc. - Applicants: Ajinomoto Co., Inc. - Inventors: Mika Hamada; Kenji Nagao; Asuka Seki - Web page: https://patentgrep.com/patent/US10765663B2 ## CPC - A61K 31/405: Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin - A23L 2/52: Adding ingredients (adding preservatives A23B70/10) - A23L 2/66: Proteins - A23L 33/175: Amino acids - A23L 33/30: {Dietetic or nutritional methods, e.g. for losing weight (A23L33/10 takes precedence)} - A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00) - A61P 1/14: Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents - A61P 3/02: Nutrients, e.g. vitamins, minerals - A61P 3/04: Anorexiants; Antiobesity agents - A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 - A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION ## Abstract The present invention provides a food intake regulating agent which improves anorexia and overeating and is safe for ingestion for a long term. The present invention relates to a food intake regulating agent containing 3 kinds of amino acids: threonine, methionine and tryptophan, as active ingredients. ## Claims ### Claim 1 A method of regulating food intake in a subject in need thereof, wherein said subject suffers from a reduction in appetite or suffers from undernutrition due to a reduction in appetite or wherein said subject suffers from overeating or a lifestyle-related disease caused by overeating, comprising administering a composition to said subject comprising, by weight percent: a) 3.5% to 40% tryptophan, b) 5% to 65% threonine, c) 6% to 45% methionine, and d) not more than 20% of isoleucine; and wherein the composition does not contain any amino acid other than tryptophan, threonine, methionine and isoleucine. ### Claim 2 (depends on 1) The method according to claim 1, wherein the composition does not contain any amino acid other than tryptophan, threonine and methionine. ### Claim 3 (depends on 1) The method according to claim 1, wherein the weight ratio of tryptophan, threonine and methionine is 1:0.5-12:0.2-10. ### Claim 4 (depends on 1) The method according to claim 1, wherein the composition further comprises isoleucine. ### Claim 5 (depends on 4) The method according to claim 4, wherein the weight ratio of tryptophan, threonine, methionine and isoleucine is 1:0.5-12:0.2-10:0.5-12. ### Claim 6 (depends on 1) The method according to claim 1, wherein the composition is in a unit packaging form for one meal and comprises, in the unit, not less than 0.06 g of amino acid to be ingested for one meal as an active ingredient. ### Claim 7 (depends on 1) The method according to claim 1, wherein the reduction in appetite is caused by a condition selected from the group consisting of aging, cancer, inflammation, decreased function of digestive organ, cardiac failure, renopathy, hepatic diseases, autoimmune disorder, lung disease, hypothyroidism, encephalopathy, anorexia nervosa, depression, dementia, Alzheimer's disease, chemotherapeutic agent, antibiotic, trauma after surgery, lack of ghrelin secretion, lack of ghrelin action, psychological stress, physical stress, irregular lifestyle habit, unbalanced diet, and combinations thereof. ### Claim 8 (depends on 1) The method according to claim 1, which is for the prophylaxis or improvement of overeating or a lifestyle-related disease caused by overeating. ### Claim 9 (depends on 8) The method according to claim 8, wherein the overeating is caused by psychological stress, physical stress, bulimia nervosa, depression, irregular lifestyle habit or low-protein diet. ### Claim 10 A method of regulating food intake of a subject in need thereof, wherein said subject suffers from a reduction in appetite or suffers from undernutrition due to a reduction in appetite, comprising administering a food or drink to said subject, wherein said food or drink is in a unit packaging form for one meal, and wherein said unit packaging form comprises not less than 0.06 g of tryptophan, threonine and methionine, wherein the weight ratio of tryptophan, threonine and methionine is 1:0.5-12:0.2-10, wherein said food or drink comprises, by weight percent: a) 3.5% to 40% tryptophan, b) 5% to 65% threonine, and c) 6% to 45% methionine; and wherein the food or drink comprises not more than 20% of isoleucine; wherein the food or drink does not contain any amino acid other than tryptophan, threonine, methionine and isoleucine. ### Claim 11 (depends on 10) The method according to claim 10, wherein the food or drink is free of an amino acid other than tryptophan, threonine and methionine. ### Claim 12 A method of regulating food intake of a subject in need thereof, wherein said subject suffers from a reduction in appetite or suffers from undernutrition due to a reduction in appetite, comprising administering a food or drink to said subject, wherein said food or drink is in a unit packaging form for one meal, and wherein said unit packaging form comprises not less than 0.06 g of tryptophan, threonine, methionine and isoleucine, wherein the weight ratio of tryptophan, threonine, methionine and isoleucine is 1:0.5-12:0.2-10:0.5 12, wherein said food or drink comprises, by weight percent: (a) 3.5%-40% tryptophan, (b) 5%-65% threonine, (c) 6%-45% methionine, and (d) 0.001%-45% isoleucine; and wherein the food or drink does not contain any amino acid other than tryptophan, threonine, methionine and isoleucine. ### Claim 13 A method of regulating food intake in a subject in need thereof, wherein said subject suffers from a reduction in appetite or suffers from undernutrition due to a reduction in appetite, comprising administering a food or drink to said subject which is in a unit packaging form for one meal, and wherein said unit packaging form comprises not less than 0.06 g of tryptophan, threonine, methionine, and isoleucine, wherein the weight ratio of tryptophan, threonine, methionine, and isoleucine is 1:0.5-12:0.2-10:-0.5-12, wherein the food or drink is free of an amino acid other than tryptophan, threonine, methionine and isoleucine. ### Claim 14 A method of regulating food intake in a subject in need thereof, wherein the subject is elderly, said method comprising administering a composition to said subject comprising by weight percent: a) 5% to 33% tryptophan, b) 8% to 60% threonine, c) 10% to 40% methionine, and d) not more than 20% of isoleucine; wherein the composition does not contain any amino acid other than tryptophan, threonine, methionine and isoleucine.