# US 10,765,655 B2 · Composition containing monoacetyldiglyceride compound as active ingredient for preventing or treating chronic obstructive pulmonary disease

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- Number: US 10,765,655 B2
- Document ID: US10765655B2
- Status: Granted
- Kind: B2
- Application number: 15/857,933
- Filed: 2017-12-29
- Published: 2018-10-04
- Granted: 2020-09-08
- Earliest claimed: 2013-08-19
- Assignees: Enzychem Lifesciences Corporation; Korea Research Institute of Bioscience and Biotechnology
- Applicants: Enzychem Lifesciences Corporation; Korea Research Institute of Bio Science and Biotechnology
- Inventors: Sei-Ryang Oh; Kyung Seop Ahn; Su Ui Lee; In Sik Shin; Ok-Kyoung Kwon; Seung Hyung Kim; Chan Mi Chun; Tae-Suk Lee; Yong-Hae Han; Ki Young Sohn; JongKoo Kang; Hye Kyung Kim
- Web page: https://patentgrep.com/patent/US10765655B2

## CPC

- A61K 31/231: having one or two double bonds
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 11/06: Antiasthmatics
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating chronic obstructive pulmonary diseases, and a functional health food composition for treating or preventing chronic obstructive pulmonary diseases. The monoacetyldiacylglycerol compound of the present invention inhibits the IL-4 expression in EL-4 cells and inhibits the infiltration of inflammatory cells into the bronchial tube in an animal model. In addition, the compounds of the present invention have an excellent effect of inhibiting the expression of CXCL-1, TNF-α, or MIP-2, thereby overcoming side effects of the currently used therapeutic agents for chronic obstructive pulmonary diseases, having no toxicity, and exhibiting a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating chronic obstructive pulmonary diseases.

## Claims

### Claim 1

A method of treating a chronic obstructive pulmonary disease in a patient, comprising administering to a patient in need of such treatment a pharmaceutically acceptable composition comprising an effective amount of a purified compound of Formula 2:

### Claim 2 (depends on 1)

The method according to claim 1, wherein the chronic obstructive pulmonary disease is chronic bronchitis.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the monoacetyldiacylglycerol compound reduces the secretion of one or more protein selected from a group consisting of IL-4, CXCL-1, TNF-.alpha. and MIP-2 levels.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the monoacetyldiacylglycerol compound reduces the number of inflammatory cells around the bronchi or vessels or the numbers of CD4+ cells and Gr-1+ neutrophils.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the chronic obstructive pulmonary disease is emphysema.