# US 10,765,654 B2 · Methods and compounds for treating cancer

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- Number: US 10,765,654 B2
- Document ID: US10765654B2
- Status: Granted
- Kind: B2
- Application number: 14/233,301
- Filed: 2012-07-19
- Published: 2014-05-22
- Granted: 2020-09-08
- Earliest claimed: 2011-07-19
- Assignees: University of Vermont and State Agricultural College
- Applicants: Diane M. Jaworski
- Inventors: Diane M. Jaworski
- Web page: https://patentgrep.com/patent/US10765654B2

## CPC

- A61K 31/225: Polycarboxylic acids
- A61K 31/166: having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A61K 31/175: having the group [IMAGE cpc-sch-A61K-0950.gif] , >N—C(O)—N=N— or[IMAGE cpc-sch-A61K-0951.gif] , e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
- A61K 31/22: of acyclic acids, e.g. pravastatin
- A61K 31/4188: condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
- A61K 31/475: having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine (vincamine A61K31/4375)
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 35/00: Antineoplastic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention includes, in part, methods and compounds for treating cancer including, but not limited to gliomas, melanomas, and neuroblastomas. In some embodiments of the invention, a glyceryltriacetate compound is administered to a subject in an amount effective to treat or prevent a cancer in the subject.

## Claims

### Claim 1

A method for treating a cancer, the method comprising administering to a subject in need of treatment of a cancer, a glyceryltriacetate (GTA) compound in a therapeutically effective amount to treat the cancer, wherein the cancer is a glioma or a neuroblastoma.

### Claim 2 (depends on 1)

The method of claim 1, wherein treating the cancer comprises decreasing cancer stem cell proliferation in the subject.

### Claim 3 (depends on 1)

The method of claim 1, wherein treating the cancer comprises enhancing the cytosolic-nuclear shuttling of aspartoacylase (ASPA) and/or acetyl-CoA synthetase 1 (AceCS1).

### Claim 4 (depends on 1)

The method of claim 1, wherein the GTA compound is administered to the subject orally, intragastrically, or is administered into a surgical incision, opening, or cavity in the subject.

### Claim 5 (depends on 1)

The method of claim 1, further comprising administering one or more additional cancer-therapeutic agents to the subject.

### Claim 6 (depends on 5)

The method of claim 5, wherein the one or more additional cancer-therapeutic agents is temozolomide, bevacizumab, bis-chloroethylnitrosourea (BCNU), Lomustine, procarbazine, or vincristine.

### Claim 7 (depends on 5)

The method of claim 5, wherein the GTA compound and the one or more additional cancer chemotherapeutic agent are administered as a combination drug therapy.

### Claim 8 (depends on 1)

The method of claim 1, further comprising administering to the subject a surgical treatment to remove or reduce the cancer in the subject.

### Claim 9 (depends on 1)

The method of claim 1, wherein the GTA compound is administered to the subject in a pharmaceutical composition.

### Claim 10 (depends on 1)

The method of claim 1, wherein the subject does not have Canavan disease.

### Claim 11 (depends on 1)

The method of claim 1, wherein the subject is a human.