# US 10,765,650 B2 · Artificial saliva

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- Number: US 10,765,650 B2
- Document ID: US10765650B2
- Status: Granted
- Kind: B2
- Application number: 16/179,846
- Filed: 2018-11-02
- Published: 2019-03-07
- Granted: 2020-09-08
- Earliest claimed: 2016-02-03
- Assignees: Forward Science Technologies, LLC
- Applicants: Forward Science Technologies, LLC
- Inventors: Brian Pikkula; Robert J. Whitman
- Web page: https://patentgrep.com/patent/US10765650B2

## CPC

- A61K 31/167: having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A61K 8/19: containing inorganic ingredients
- A61K 8/20: Halogens; Compounds thereof
- A61K 8/24: Phosphorous; Compounds thereof
- A61K 8/42: Amides
- A61K 8/445: {aromatic, i.e. the carboxylic acid directly linked to the aromatic ring}
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 9/08: Solutions {(composition of solutions A61K47/00)}
- A61K 31/245: Amino benzoic acid types, e.g. procaine, novocaine (salicylic acid esters A61K31/60)
- A61K 33/00: Medicinal preparations containing inorganic active ingredients
- A61K 33/06: Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay}
- A61K 33/42: Phosphorus; Compounds thereof
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 47/02: Inorganic compounds
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

A composition for mixing with water for use as an oral rinse, comprising monobasic sodium phosphate, dibasic sodium phosphate, sodium chloride, calcium chloride, and an analgesic/anaesthetic such as benzocaine/lidocaine.

## Claims

### Claim 1

An oral rinse composition comprising an oral care mixture to be dissolved in water to form an oral rinse solution, supersaturated in calcium phosphate, for use in a human oral cavity, wherein the oral care mixture consists of, by weight:
from 0.5% to 5.0% of monobasic sodium phosphate;
from 0.5% to 5.0% dibasic sodium phosphate;
from 40.0% to 75.0% of sodium chloride;
from 10.0% to 30.0% of calcium chloride;
from 0.5% to 5.0% of silicon dioxide; and
a therapeutically effective amount of benzocaine and/or lidocaine as an analgesic and/or anaesthetic.

### Claim 2 (depends on 1)

The oral rinse composition of claim 1 wherein the therapeutically effective amount of benzocaine and/or lidocaine is from 5.0% to 50.0%, by weight.

### Claim 3 (depends on 1)

The oral rinse composition of claim 1 wherein the therapeutically effective amount of benzocaine and/or lidocaine is such that the composition provides at least a 5.0 w/v % solution of benzocaine and/or lidocaine when the composition is dissolved in 0.1 oz (3 mL) of water.

### Claim 4 (depends on 1)

An oral rinse solution consisting of water and the oral care mixture of claim 1 dissolved therein to form a supersaturated calcium phosphate solution.

### Claim 5 (depends on 4)

Artificial saliva consisting essentially of the oral rinse solution of claim 4.

### Claim 6 (depends on 2)

An oral rinse solution consisting of water and the oral care mixture of claim 2 dissolved therein to form a supersaturated calcium phosphate solution.

### Claim 7 (depends on 6)

Artificial saliva consisting essentially of the oral rinse solution of claim 6.

### Claim 8 (depends on 3)

An oral rinse solution consisting of water and the oral care mixture of claim 3 dissolved therein to form a supersaturated calcium phosphate solution.

### Claim 9 (depends on 8)

Artificial saliva consisting essentially of the oral rinse solution of claim 8.