# US 10,765,647 B2 · Composition for treating diabetes, containing extract of yukmijihwangtang

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- Number: US 10,765,647 B2
- Document ID: US10765647B2
- Status: Granted
- Kind: B2
- Application number: 15/970,282
- Filed: 2018-05-03
- Published: 2019-02-14
- Granted: 2020-09-08
- Earliest claimed: 2013-05-07
- Assignees: Comprehensive and Integrative Medicine Institute
- Applicants: Comprehensive and Integrative Medicine Institute
- Inventors: Seok Bong Kang; Ho Sang Sohn; Joon Seok Byun; Ki Cheul Sohn; Sae Kwang Ku
- Web page: https://patentgrep.com/patent/US10765647B2

## CPC

- A61K 31/155: Amidines ([IMAGE cpc-sch-A61K-1029.gif]), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A61K 36/076: Poria
- A61K 36/40: Cornaceae (Dogwood family)
- A61K 36/53: Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K 36/65: Paeoniaceae (Peony family), e.g. Chinese peony
- A61K 36/804: Rehmannia
- A61K 36/884: Alismataceae (Water-plantain family)
- A61K 36/8945: Dioscorea, e.g. yam, Chinese yam or water yam
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided is a composition for treating diabetes, including a hypoglycemic agent and a Yukmijihwang-tang extract. More particularly, the hypoglycemic agent is administered into an individual, and the Yukmijihwang-tang extract is administered into the individual, thereby considerably increasing a hypoglycemic effect of the hypoglycemic agent, and preventing and reducing various diabetic complications such as diabetes and diabetic liver damage, renal damage, hyperlipidemia immunosuppression and ocular damage.

## Claims

### Claim 1

A method for treating type I diabetes, comprising:
administering a composition comprising metformin and a composition comprising Yukmijihwang-tang extract to a subject in need thereof,
wherein the Yukmijihwang-tang extract comprises Rehmanniae Radix Preparat, Dioscoreae Rhizoma, Corni Fructus, Alismatis Rhizoma, Hoelen, and Moutan Cortex with the weight ratio of 2:1:1:1:1:1.

### Claim 2 (depends on 1)

The method of claim 1, wherein the composition comprising metformin and the composition comprising Yukmijihwang-tang extract are separately formulated.

### Claim 3 (depends on 1)

The method of claim 1, wherein the composition comprising metformin and the composition comprising Yukmijihwang-tang extract are parenterally, orally, regionally, or percutaneously administered.

### Claim 4 (depends on 1)

The method of claim 1, wherein the composition comprising Yukmijihwang-tang extract is administered within 30 minutes to 4 hours after the administration of the composition comprising metformin.

### Claim 5 (depends on 1)

The method of claim 1, wherein the metformin and the composition comprising Yukmijihwang-tang extract are formulated together and are administered to the subject in a dose of from 0.001 to 300 mg/kg (body weight).

### Claim 6 (depends on 5)

The method of claim 5, wherein the metformin and the composition comprising Yukmijihwang-tang extract are administered to the subject in a dose of from 0.01 to 200 mg/kg (body weight), taken together.

### Claim 7 (depends on 1)

The method of claim 1, wherein the Yukmijihwang-tang extract is administered to the subject in a dose ranging from 100 mg/kg through 400 mg/kg.

### Claim 8 (depends on 1)

The method of claim 1, wherein the Yukmijihwang-tang extract is administered to the subject in a dose of 100 mg/kg, 200 mg/kg or 400 mg/kg.

### Claim 9 (depends on 1)

The method of claim 1, wherein the Yukmijihwang-tang extract and the metformin are administered orally.

### Claim 10 (depends on 2)

The method of claim 2, wherein the Yukmijihwang-tang extract is administered before the metformin is administered.

### Claim 11 (depends on 1)

The method of claim 1, wherein the metformin is administered at a dose of 500 mg/kg.