# US 10,765,642 B2 · Composition for preventing or treating muscle weakness-related diseases comprising sobrerol

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- Number: US 10,765,642 B2
- Document ID: US10765642B2
- Status: Granted
- Kind: B2
- Application number: 15/758,595
- Filed: 2016-09-09
- Published: 2018-08-30
- Granted: 2020-09-08
- Earliest claimed: 2015-09-09
- Assignees: Korea Research Institute of Bioscience and Biotechnology; Seoul National University R&Db Foundation
- Applicants: Korea Research Institute of Bioscience and Biotechnology; Seoul National University R&Db Foundation
- Inventors: Ki Sun Kwon; Jeongi Choi; Sung Sup Park; Sun Gun Chung; Eun Soo Kwon; Kwang-Pyo Lee; Seung Min Lee
- Web page: https://patentgrep.com/patent/US10765642B2

## CPC

- A61K 31/047: having two or more hydroxy groups, e.g. sorbitol
- A23K 20/105: Aliphatic or alicyclic compounds
- A23K 50/50: for rodents
- A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21)
- C12N 5/0658: {Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts}
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- C12N 2500/30: Organic components
- C12N 2501/999: Small molecules not provided for elsewhere
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23K: FODDER
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

The present invention relates to sobrerol or a pharmaceutically acceptable salt thereof, which can promote differentiation of myoblasts to form myotubes, thereby preventing muscle weakness and effectively improving muscle functions. Therefore, the pharmaceutical composition containing the same can be effectively used for preventing or treating muscle weakness related diseases.

## Claims

### Claim 1

A method for treating a subject suffering from muscle weakness-related disease, comprising administering an effective amount of a composition comprising sobrerol or a pharmaceutically acceptable salt thereof to the subject,
wherein the muscle weakness-related disease is age-related sarcopenia.

### Claim 2

A method for increasing muscle strength in a subject suffering from a muscle weakness-related disease, comprising administering an effective amount of a composition comprising sobrerol or a pharmaceutically acceptable salt thereof to the subject,
wherein the muscle weakness-related disease is age-related sarcopenia.

### Claim 3 (depends on 1)

The method of claim 1, wherein the composition is selected from the group consisting of a pharmaceutical composition, a health functional food, a feed, and a feed additive.

### Claim 4 (depends on 1)

The method of claim 1, wherein a concentration of the sobrerol in the composition ranges from 0.01 nM to 1 μM.

### Claim 5 (depends on 2)

The method of claim 2, wherein the composition is selected from the group consisting of a pharmaceutical composition, a health functional food, a feed, and a feed additive.

### Claim 6 (depends on 2)

The method of claim 2, wherein a concentration of the sobrerol in the composition ranges from 0.01 nM to 1 μM.

### Claim 7 (depends on 1)

The method of claim 1, wherein the administering the composition increases a size of muscle cells in the subject.

### Claim 8 (depends on 1)

The method of claim 1, wherein the administering the composition increases a weight of muscle cells in the subject.

### Claim 9 (depends on 2)

The method of claim 2, wherein the administering the composition increases a size of muscle cells in the subject.

### Claim 10 (depends on 2)

The method of claim 2, wherein the administering the composition increases a weight of muscle cells in the subject.