# US 10,765,639 B2 · Nanocapsules, methods of manufacture and uses thereof

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- Number: US 10,765,639 B2
- Document ID: US10765639B2
- Status: Granted
- Kind: B2
- Application number: 16/088,242
- Filed: 2017-03-17
- Published: 2019-03-21
- Granted: 2020-09-08
- Earliest claimed: 2016-03-25
- Assignees: Adisseo France S.A.S.
- Applicants: Adisseo France S.A.S.
- Inventors: Damien Preveraud; Véronique Rosilio
- Web page: https://patentgrep.com/patent/US10765639B2

## CPC

- A61K 9/5192: {Processes}
- A23K 10/30: from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms (obtained by microbiological or biochemical processes, e.g. using yeasts or enzymes, A23K10/10)
- A23K 20/158: Fatty acids; Fats; Products containing oils or fats
- A23K 20/174: Vitamins
- A23K 40/30: by encapsulating; by coating
- A23K 50/75: for poultry
- A61K 9/5015: {Organic compounds, e.g. fats, sugars}
- A61K 9/5123: {Organic compounds, e.g. fats, sugars}
- A61K 9/5161: {Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin}
- A61K 31/07: Retinol compounds, e.g. vitamin A (retinoic acids A61K31/203)
- A61K 31/122: having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K 31/355: Tocopherols, e.g. vitamin E
- A61K 31/593: 9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23K: FODDER

## Abstract

The invention concerns nanocapsules in the form of a colloidal suspension or in dry form, said nanocapsules comprising at least an active ingredient in the form of an oil, one ionic surfactant, optionally one nonionic surfactant, and one hydrophilic polymer. The invention also concerns their manufacture and their uses.

## Claims

### Claim 1

Nanocapsules comprising an oily fraction comprising an active ingredient in the form of an oil, an ionic surfactant, a nonionic surfactant, and a hydrophilic polymer surrounding said oily fraction, wherein said ionic surfactant and said hydrophilic polymer have opposite charges.

### Claim 2 (depends on 1)

The nanocapsules according to claim 1, wherein said active ingredient comprises at least one of vitamin A, vitamin D, vitamin E, vitamin K and their derivatives and their metabolites, essential oils, fatty acids, fatty oils and any mixtures thereof.

### Claim 3 (depends on 2)

The nanocapsules according to claim 2, wherein said active ingredient comprises an essential oil of at least one of thyme, oregano, rosemary, garlic, camellia, mustard, ginger, turmeric, grape, citrus fruits, sainfoin, yucca, mugwort, cinnamon, mint, clove, berries, cumin and Echinacea.

### Claim 4 (depends on 1)

The nanocapsules according to claim 1, wherein said ionic surfactant has a molecular weight of at most 1500 g/mol.

### Claim 5 (depends on 1)

The nanocapsules according to claim 1, wherein the ionic surfactant comprises at least one of phosphatidylcholines and hexadecyltrimethylammonium bromide.

### Claim 6 (depends on 1)

The nanocapsules according to claim 1, wherein said nonionic surfactant comprises at least one of polyoxyethylene-polyoxypropylene block copolymers, blends of polyoxyethylene (EO)-polyoxypropylene (PO) block copolymer, Tween 80, fatty acids and sucrose esters, and any mixture thereof.

### Claim 7 (depends on 6)

The nanocapsules according to claim 6, wherein the polyoxyethylene-polyoxypropylene block copolymer(s) comprise at least one of copolymers of formula EOx—POy-EOx wherein x ranges from 75 to 85 and y ranges from 25 to 35, copolymers of formula EOx—POy-EOx wherein x ranges from 55 to 65 and y ranges from 35 to 45 and copolymers of formula EOx—POy-EOx wherein x ranges from 112 to 123 and y ranges from 40 to 50.

### Claim 8 (depends on 6)

The nanocapsules according to claim 6, wherein the fatty acids and sucrose esters comprise at least one of stearates and palmitates.

### Claim 9 (depends on 1)

The nanocapsules according to claim 1, wherein said polymer comprises at least one of chitosan, alginate, pectin, starch, cellulose, casein and combinations thereof.

### Claim 10 (depends on 1)

The nanocapsules according to claim 1, wherein the content of said active ingredient is of at least 5% by mass relative to the dry mass of the nanocapsules.

### Claim 11 (depends on 1)

The nanocapsules according to claim 1, wherein the content of said nonionic surfactant is of at least 15% by weight relative to the dry mass of the nanocapsules.

### Claim 12 (depends on 1)

The nanocapsules according to claim 1, adsorbed on lactose.

### Claim 13 (depends on 1)

The nanocapsules according to claim 1, configured to be implemented in animal nutrition.

### Claim 14 (depends on 13)

The nanocapsules according to claim 13, configured to be implemented in monogastrics.