# US 10,765,623 B2 · Composition for preventing hair loss or promoting hair growth comprising extracellular follicle derived from lactic acid bacteria

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- Number: US 10,765,623 B2
- Document ID: US10765623B2
- Status: Granted
- Kind: B2
- Application number: 15/760,908
- Filed: 2016-09-26
- Published: 2018-09-13
- Granted: 2020-09-08
- Earliest claimed: 2015-09-30
- Assignees: Amorepacific Corporation
- Applicants: Amorepacific Corporation
- Inventors: Sung Tae Kim; Yonghee Lee; Seung Hyun Shin; Hyun Gee Lee; Eun-Gyung Cho; Tae Ryong Lee
- Web page: https://patentgrep.com/patent/US10765623B2

## CPC

- A61K 8/99: from microorganisms other than algae or fungi, e.g. protozoa or bacteria
- A61K 8/14: Liposomes; Vesicles
- A61K 35/744: Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K 35/745: Bifidobacteria
- A61K 35/747: Lactobacilli, e.g. L. acidophilus or L. brevis
- A61P 17/14: for baldness or alopecia
- A61Q 7/00: Preparations for affecting hair growth
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present specification discloses a composition for preventing hair loss or promoting hair growth comprising, as an active ingredient, extracellular follicles derived from lactic acid bacteria, and a method for preparing the extracellular follicles derived from lactic acid bacteria. The composition has an effect of preventing and prohibiting hair from falling off from the scalp or becoming thin or tapered. In addition, the composition has an effect of implementing a hair growth function for generating new hair, or a function for promoting the hair growth, as well as a function of promoting a delay from an anagen to a catagen phase of a hair cycle and a function of growing the existing hair healthy.

## Claims

### Claim 1

A method for promoting hair growth, comprising administering an effective amount of extracellular vesicles isolated from lactic acid bacteria for promoting hair growth to a subject in need thereof;
wherein the lactic acid bacterium comprises a bacterium in the genus Lactobacillus and wherein the extracellular vesicles are administered at a concentration of 0.1-100 μg/mL.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the bacterium in the genus Lactobacillus comprises one or more selected from the group consisting of Lactobacillus reuteri (L. reuteri), Lactobacillus rhamnosus (L. rhamnosus) and Lactobacillus sakei (L. sakei).

### Claim 3 (depends on 1)

The method according to claim 1, wherein the extracellular vesicle is isolated from a culture of lactic acid bacteria.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the extracellular vesicle is an exosome-like vesicle.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the extracellular vesicle has a diameter of 20-500 nm.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the extracellular vesicle precipitates when a culture of lactic acid bacteria is ultracentrifuged at 100,000×g or higher.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the extracellular vesicle induces hair growth by activating dermal papilla cells (DPCs).