# US 10,765,621 B2 · Extracts of halimione portulacoides and their application

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- Number: US 10,765,621 B2
- Document ID: US10765621B2
- Status: Granted
- Kind: B2
- Application number: 15/023,157
- Filed: 2014-09-16
- Published: 2016-08-11
- Granted: 2020-09-08
- Earliest claimed: 2013-09-22
- Assignees: Symrise AG
- Applicants: Cutech Srl
- Inventors: Lorenzo Zanella; Paolo Pertile
- Web page: https://patentgrep.com/patent/US10765621B2

## CPC

- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 8/97: from algae, fungi, lichens or plants; from derivatives thereof
- A61K 36/21: Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
- A61Q 7/00: Preparations for affecting hair growth
- A61Q 19/04: for chemically tanning the skin (topical sun or radiation screening or tanning preparations A61Q17/04)
- A61Q 19/08: Anti-ageing preparations
- A61K 2236/00: Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K 2800/805: Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

New extracts are suggested of Halimione portulacoides or sea purslane, and related species of Halimione, obtainable by treating the said plant with a solvent selected from the group consisting of C1-C4 aliphatic alcohols, ethyl acetate, water or their mixtures, removing the dissolved extracts from the residues and recovering the pure extracts from the solvent. The extracts show excellent properties particularly in modulating the metabolism of human skin and hair follicles.

## Claims

### Claim 1

A non-pharmaceutical method comprising topically administering an effective amount of an extract of Halimione sp. to skin or scalp of a subject suffering from hair loss and/or whitening or in need of promoting hair follicle growth and/or pigmentation, for modulating
(i) keratinocyte differentiation in human hair, and/or
(ii) melamin synthesis in human hair follicles, and/or
(iii) hair growth by improving general wellness of the organ and/or by delaying the catagen in the human hair follicles.

### Claim 2 (depends on 1)

The method of claim 1, comprising the additional step of obtaining the extract of Halimione sp. by treating the plant with a solvent selected from the group consisting of C1-C4 aliphatic alcohols, ethyl acetate, water and mixtures thereof, removing the dissolved extracts from the residues and recovering the pure extracts from the solvent.

### Claim 3 (depends on 2)

The method of claim 2, comprising the following steps:
(a) bringing the plant material, optionally minced or crushed or micronized, in contact with a solvent selected from the group consisting of C1-C4 aliphatic alcohols, ethyl acetate, water and mixtures thereof in an amount suitable for the active ingredients to move into the solvent phase, optionally at elevated temperatures,
(b) removing the dissolved extract from the residue, and
(c) recovering the pure extract from the solvent.

### Claim 4 (depends on 1)

The method of claim 1, comprising topically administering the extract of Halimione sp. together with a cosmetically acceptable carrier selected from the group consisting of C1-C4 aliphatic alcohols, polyols having 3 to 12 carbon atoms, oil components, water and mixtures thereof.

### Claim 5 (depends on 1)

The method of claim 1, wherein the extract is administered in an amount of from about 0.001 to about 35% b.w.—calculated on the final composition.

### Claim 6 (depends on 5)

The method of claim 5, comprising administering the extract in an amount of about 0.01 to about 10% by weight.

### Claim 7 (depends on 6)

The method of claim 6, comprising administering the extract in an amount of about 0.1 to about 3% by weight.