# US 10,765,616 B2 · Oral formulation of polyglucosamine derivatives in combination with a non-fermentable sugar

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- Number: US 10,765,616 B2
- Document ID: US10765616B2
- Status: Granted
- Kind: B2
- Application number: 15/948,446
- Filed: 2018-04-09
- Published: 2018-10-11
- Granted: 2020-09-08
- Earliest claimed: 2013-03-12
- Assignees: Synedgen, Inc.
- Applicants: Synedgen, Inc.
- Inventors: Stacy M. Townsend; Shenda M. Baker; William P. Wiesmann
- Web page: https://patentgrep.com/patent/US10765616B2

## CPC

- A61K 8/736: {Chitin; Chitosan; Derivatives thereof}
- A61C 17/20: using ultrasonic waves
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/368: with carboxyl groups directly bound to carbon atoms of aromatic rings
- A61K 8/4993: {Derivatives containing from 2 to 10 oxyalkylene groups}
- A61K 8/922: {of vegetable origin}
- A61K 31/047: having two or more hydroxy groups, e.g. sorbitol
- A61K 31/155: Amidines ([IMAGE cpc-sch-A61K-1029.gif]), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A61K 31/4164: 1,3-Diazoles
- A61K 31/722: Chitin, chitosan
- A61K 31/726: Glycosaminoglycans, i.e. mucopolysaccharides (chondroitin sulfate, dermatan sulfate A61K31/737)
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q 17/005: {Antimicrobial preparations}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61C: DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE (non-driven toothbrushes A46B; {tongue scrapers A61B17/24;} preparations for dentistry A61K6/00; preparations for cleaning the teeth or mouth A61K8/00, A61Q11/00)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Described herein are methods and compositions that contain a soluble polyglucosamine or polyglucosamine derivative for use in oral health. The compositions are useful for, e.g., reducing bacteria (e.g., by clumping and removing) or disrupting a biofilm in the mouth of a subject, reducing dry mouth, and reducing oral inflammation.

## Claims

### Claim 1

A method of treating dry mouth, the method comprising administering to a subject an oral care aqueous composition comprising:
sorbitol present in the composition at an amount from about 5% to about 35% by weight of the composition;
xylitol present in the composition at an amount from about 2% to about 15% by weight of the composition; and
a poly (acetyl, arginyl) glucosamine (PAAG), wherein PAAG comprises the following formula (I):
wherein:
n is an integer between 20 and 6000; and
each R1 is independently selected for each occurrence from hydrogen, acetyl,
wherein at least 25% of R1 substituents are H, at least 1% of R1 substituents are acetyl, and at least 2% of R1 substituents are
the molecular weight of the PAAG is from 20 to 200 kDa, and wherein the PAAG is present in the composition at an amount of at least 0.003% to about 0.05% w/v of the composition.

### Claim 2 (depends on 1)

The method of claim 1, wherein the composition further comprises:
glycerin; and
a flavoring agent.

### Claim 3 (depends on 1)

The method of claim 1, wherein the PAAG is functionalized at from about 5% to about 50%.

### Claim 4 (depends on 1)

The method of claim 1, wherein the pH is from about 6 to about 8.