# US 10,765,609 B2 · Oral composition > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,765,609 B2 - Document ID: US10765609B2 - Status: Granted - Kind: B2 - Application number: 16/305,643 - Filed: 2017-05-29 - Published: 2019-11-28 - Granted: 2020-09-08 - Earliest claimed: 2016-05-31 - Assignees: Kao Corporation - Applicants: Kao Corporation - Inventors: Noritaka Takahashi; Ryosuke Nagata; Takuya Asada - Web page: https://patentgrep.com/patent/US10765609B2 ## CPC - A61K 8/21: Fluorides; Derivatives thereof - A61K 8/24: Phosphorous; Compounds thereof - A61K 8/26: Aluminium; Compounds thereof - A61K 8/342: {Alcohols having more than seven atoms in an unbroken chain} - A61K 8/36: Carboxylic acids; Salts or anhydrides thereof - A61K 8/361: {Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof} - A61K 8/49: containing heterocyclic compounds - A61K 8/4973: {with oxygen as the only hetero atom} - A61K 8/4993: {Derivatives containing from 2 to 10 oxyalkylene groups} - A61K 8/86: Polyethers - A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses - A61K 2800/28: Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract The present invention is directed to an oral composition having an improved ability to incorporate fluoride ions into tooth enamel and an enhanced remineralization effect. ## Claims ### Claim 1 An oral composition comprising the following ingredients (A), (B), (C), and (D): (A) 0.005 mass % or more and 2 mass % or less, in terms of fluorine atoms, of one or more fluoride ion-supplying compounds selected from the group consisting of sodium fluoride, ammonium fluoride, potassium fluoride, sodium monofluorophosphate, and tin fluoride; (B) 4 mass % or more and 30 mass % or less of a higher alcohol having 12 or more and 22 or less carbon atoms comprising (b1) cetanol and (b2) stearyl alcohol; (C) 0.1 mass % or more and 10 mass % or less of a surfactant comprising one or more selected from the group consisting of (c1) a nonionic surfactant selected from the group consisting of sorbitan fatty acid ester and polyoxyethylene sorbitan fatty acid ester and (c2) an anionic surfactant being fatty acid having 12 or more and 22 or less carbon atoms or a salt thereof; and (D) water, wherein the content of the ingredient (c1) is 0.05 mass % or more; a mass ratio of the content of the ingredient (A) in terms of fluorine atoms to the content of the ingredient (B), (A)/(B), is 0.001 or more and 0.2 or less; and the molar amount of (E) a polyvalent metal compound other than the ingredient (A) is less than 0.1-fold the molar amount of the ingredient (A). ### Claim 2 (depends on 1) The oral composition according to claim 1, wherein when the ingredient (C) does not contain the ingredient (c2), a mass ratio of the content of the ingredient (B) to the content of the ingredient (c1), (B)/(c1), is 1 or more and 10 or less; and when the ingredient (C) contains both the ingredient (c1) and the ingredient (c2), a mass ratio of the content of the ingredient (B) to the content of the ingredient (c1), (B)/(c1), is 1 or more and 10 or less; and a mass ratio of the content of the ingredient (B) to the content of the ingredient (c2), (B)/(c2), is 2 or more and 180 or less. ### Claim 3 (depends on 1) The oral composition according to claim 1, wherein a mass ratio of the content of the ingredient (b1) to the content of the ingredient (b2), ((b1)/(b2)), is 0.5 or more and 5 or less. ### Claim 4 (depends on 1) The oral composition according to claim 1, wherein a mass ratio of the sum of the content of the ingredient (b1) and the content of the ingredient (b2) to the content of the ingredient (B), (((b1)+(b2))/(B)), is 0.85 or more and 1 or less. ### Claim 5 (depends on 1) The oral composition according to claim 1, wherein the content of a cellulose binder is 0.3 mass % or less. ### Claim 6 (depends on 5) The oral composition according to claim 5, wherein the cellulose binder is one or two selected from the group consisting of sodium carboxymethyl cellulose and hydroxyalkyl cellulose. ### Claim 7 (depends on 1) The oral composition according to claim 1, wherein the content of a water-absorbing ingredient being solid at 20° C. and selected from the group consisting of abrasive silica, sorbitol, and xylitol is 30 mass % or less. ### Claim 8 (depends on 1) The oral composition according to claim 1, wherein a mass ratio of the content of the ingredient (B) to the sum of the content of the ingredient (c1) and the content of the ingredient (c2) in terms of fatty acids, (B)/((c1)+(c2)), is higher than 1 and 40 or less. ### Claim 9 (depends on 1) The oral composition according to claim 1, wherein a mass ratio of the content of (F) oil other than the ingredient (B), the ingredient (C), an oil-soluble medicinal ingredient, and a flavoring agent to the content of the ingredient (B), (F)/(B), is less than 1. ### Claim 10 (depends on 1) The oral composition according to claim 1, wherein the content of the ingredient (D) is 50 mass % or more and 95 mass % or less. ### Claim 11 (depends on 1) The oral composition according to claim 1, wherein the content of polyoxyethylene hydrogenated castor oil is 0.5 mass % or less. ### Claim 12 (depends on 1) The oral composition according to claim 1, wherein the composition is an agent for promoting incorporation of fluoride ions into teeth. ### Claim 13 (depends on 1) A method of producing the oral composition according to claim 1, comprising: a step (I) of mixing a mixture liquid comprising the ingredient (B) and the ingredient (C) at a temperature not lower than the melting point of the ingredient (B) and not higher than 90° C.; and a step (II) of adding thereto the ingredient (A). ### Claim 14 (depends on 1) A method for incorporating fluoride ions into teeth by applying the composition according to claim 1 into the oral cavity. ### Claim 15 An oral composition comprising the following ingredients (A), (B), (C), and (D): (A) 0.005 mass % or more and 2 mass % or less, in terms of fluorine atoms, of one or more fluoride ion-supplying compounds selected from the group consisting of sodium fluoride, ammonium fluoride, potassium fluoride, sodium monofluorophosphate, and tin fluoride; (B) 4 mass % or more and 30 mass % or less of a higher alcohol having 12 or more and 22 or less carbon atoms comprising (b1) cetanol and (b2) stearyl alcohol; (C) 0.1 mass % or more and 10 mass % or less of a surfactant comprising one or more selected from the group consisting of (c1) a nonionic surfactant selected from the group consisting of sorbitan fatty acid ester and polyoxyethylene sorbitan fatty acid ester and (c2) an anionic surfactant being fatty acid having 12 or more and 22 or less carbon atoms or a salt thereof; and (D) water, wherein: the content of the ingredient (c1) is 0.05 mass % or more; a mass ratio of the content of the ingredient (A) in terms of fluorine atoms to the content of the ingredient (B), (A)/(B), is 0.001 or more and 0.2 or less; the molar amount of (E) a polyvalent metal compound other than the ingredient (A) is less than 0.1-fold the molar amount of the ingredient (A); wherein, when the ingredient (C) does not contain the ingredient (c2), a mass ratio of the content of the ingredient (B) to the content of the ingredient (c1), (B)/(c1), is 1 or more and 10 or less; when the ingredient (C) contains both the ingredient (c1) and the ingredient (c2), a mass ratio of the content of the ingredient (B) to the content of the ingredient (c1), (B)/(c1), is 1 or more and 10 or less and a mass ratio of the content of the ingredient (B) to the content of the ingredient (c2), (B)/(c2), is 2 or more and 180 or less. ### Claim 16 (depends on 1) The oral composition of claim 1, wherein the content of the ingredient (c1) is 0.05 mass % or more and 10 mass % or less. ### Claim 17 (depends on 15) The oral composition of claim 15, wherein the content of the ingredient (c1) is 0.05 mass % or more and 10 mass % or less.