# US 10,765,512 B2 · Cardiac repair prosthesis sets and methods > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,765,512 B2 - Document ID: US10765512B2 - Status: Granted - Kind: B2 - Application number: 15/829,190 - Filed: 2017-12-01 - Published: 2018-04-26 - Granted: 2020-09-08 - Earliest claimed: 2013-07-18 - Assignees: The Trustees of the University of Pennsylvania - Applicants: The Trustees Of The University Of Pennsylvania - Inventors: Bartosz Rylski; Joseph Bavaria; Rita Carrie Milewski - Web page: https://patentgrep.com/patent/US10765512B2 ## CPC - A61F 2/2412: {with soft flexible valve members, e.g. tissue valves shaped like natural valves} - A61B 17/122: Clamps or clips, e.g. for the umbilical cord {(for the vas deferens A61F6/206)} - A61B 17/128: for applying or removing clamps or clips - A61F 2/07: Stent-grafts - A61F 2/2418: {Scaffolds therefor, e.g. support stents} - A61F 2/89: the wire-like elements comprising two or more adjacent rings flexibly connected by separate members - A61F 2220/0025: Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements - A61F 2220/0075: sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable - A61F 2220/0091: connected by a hinged linkage mechanism, e.g. of the single-bar or multi-bar linkage type - A61F 2250/0097: Visible markings, e.g. indicia - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Cardiac repair prostheses, sets, and methods for implanting in an aorta are disclosed. Cardiac repair prosthesis sets can include a radially expandable support supporting a unidirectional valve that is configured for implantation into the aortic valve region of a patient and a second radially expandable support for a substantially blood impervious stent having a size and shape for implantation into the ascending aorta of said patient where the unidirectional valve and stent are configured for integration within the patient by at least one joining element. Cardiac repair prostheses can include a radially expandable support supporting a unidirectional valve configured for implantation into the aortic valve region of a patient and a second radially expandable support for a substantially blood impervious stent having a size and shape for implantation into the ascending aorta of said patient where the unidirectional valve and stent are joined by at least one joining element. ## Claims ### Claim 1 A cardiac repair prosthesis comprising: a first radially expandable scaffolding comprising a unidirectional valve configured for implantation into the aortic valve region of a patient; and a second radially expandable scaffolding having a size and shape for implantation into the ascending aorta of said patient; the first radially expandable scaffolding and the second radially expandable scaffolding being joined by at least one joining element, and, at least one portion of the first radially expandable scaffolding having a diameter that is different from a diameter of at least one portion the second radially expandable scaffolding. ### Claim 2 (depends on 1) The cardiac repair prosthesis of claim 1 wherein the at least one joining element comprises a suture. ### Claim 3 (depends on 1) The cardiac repair prosthesis of claim 1, wherein the at least one joining element comprises a clip. ### Claim 4 (depends on 3) The cardiac repair prosthesis of claim 3, wherein the clip has a hinge and locking mechanism. ### Claim 5 (depends on 1) The cardiac repair prosthesis of claim 1, wherein the unidirectional valve comprises one or more leaflets. ### Claim 6 (depends on 1) The cardiac repair prosthesis of claim 1, wherein the unidirectional valve comprises two or three leaflets. ### Claim 7 (depends on 5) The cardiac repair prosthesis of claim 5, wherein the leaflets comprise a biological material. ### Claim 8 (depends on 5) The cardiac repair prosthesis of claim 5, wherein the leaflets comprise a synthetic material. ### Claim 9 (depends on 1) The cardiac repair prosthesis of claim 1, wherein the first radially expandable scaffolding is partially covered by a material that is substantially impervious to blood. ### Claim 10 (depends on 1) The cardiac repair prosthesis of claim 1, wherein the first radially expandable scaffolding is configured for implantation in the aortic annulus of a patient. ### Claim 11 (depends on 1) The cardiac repair prosthesis of claim 1, wherein a longitudinal end of the first radially expandable scaffolding is joined to a longitudinal end of the second radially expandable scaffolding by the at least one joining element. ### Claim 12 (depends on 1) The cardiac repair prosthesis of claim 1, wherein the second radially expandable scaffolding is at least partially covered by a material that is substantially impervious to blood. ### Claim 13 (depends on 1) The cardiac repair prosthesis of claim 1, wherein the second radially expandable scaffolding includes a first longitudinal end and a second longitudinal end, wherein a diameter of the second radially expandable scaffolding at the first longitudinal end is different than a diameter of the second radially expandable scaffolding at the second longitudinal end. ### Claim 14 (depends on 1) The cardiac repair prosthesis according to claim 1, wherein at least a portion of the first radially expandable scaffolding has a diameter that is less than a diameter of at least one portion the second radially expandable scaffolding.