# US 10,765,500 B2 · Temporarily stiffened mesh prostheses > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,765,500 B2 - Document ID: US10765500B2 - Status: Granted - Kind: B2 - Application number: 15/975,273 - Filed: 2018-05-09 - Published: 2018-09-13 - Granted: 2020-09-08 - Earliest claimed: 2006-02-08 - Assignees: Medtronic, Inc. - Applicants: Tyrx, Inc. - Inventors: Fatima Buevich; Frank Do; William McJames; Satish Pulapura; William Edelman; Arikha Moses; Mason Diamond; Shari Timothy - Web page: https://patentgrep.com/patent/US10765500B2 ## CPC - A61F 2/0063: {Implantable repair or support meshes, e.g. hernia meshes} - A61L 27/34: Macromolecular materials - A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} - A61L 27/56: Porous materials, {e.g. foams or sponges} - A61L 27/58: Materials at least partially resorbable by the body - A61L 31/10: Macromolecular materials - A61L 31/146: {Porous materials, e.g. foams or sponges} - A61L 31/148: {Materials at least partially resorbable by the body} - A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} - A61P 23/02: Local anaesthetics - A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics - A61F 2210/0004: bioabsorbable - A61F 2250/0067: Means for introducing or releasing pharmaceutical products into the body - A61F 2310/0097: Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics - A61L 2300/402: Anaestetics, analgesics, e.g. lidocaine - A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents - A61L 2300/406: Antibiotics - A61L 2300/416: Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus - A61L 2300/45: Mixtures of two or more drugs, e.g. synergistic mixtures - A61L 2300/606: Coatings - A61L 2430/02: for reconstruction of bones; weight-bearing implants - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use. By including biologically active agents and/or drugs in the coating, the devices provide prophylaxis for and can alleviate side effects or complications associated with the surgery or use of prostheses in general. ## Claims ### Claim 1 A medical prosthesis comprising: a surgical mesh with a coating, the coating including a first layer and a second layer, the first layer being positioned between the mesh and the second layer, wherein the coating is applied to the mesh without substantially altering a porosity of the mesh, wherein the first layer comprises a first polymer and the second layer comprises a second polymer that is different than the first polymer, and wherein at least one of the polymers comprises a tyrosine-derived polyarylate. ### Claim 2 (depends on 1) A medical prosthesis as recited in claim 1, wherein the second polymer comprises the tyrosine-derived polyarylate and the first polymer is hydrophilic and comprises a water soluble drug. ### Claim 3 A medical prosthesis comprising: a surgical mesh with a coating, the coating including a first layer and a second layer, the first layer being positioned between the mesh and the second layer, the first layer comprising a water soluble polymer, the second layer comprising a non-water soluble polymer, wherein the coating is applied to the mesh without substantially altering a porosity of the mesh, wherein the first layer comprises a water soluble drug that is dissolved in the water soluble polymer, and wherein the non-water soluble polymer comprises a tyrosine-derived polyarylate. ### Claim 4 (depends on 1) A medical prosthesis as recited in claim 1, wherein the second polymer comprises the tyrosine-derived polyarylate and the first polymer is hydrophilic and comprises chitosan. ### Claim 5 (depends on 1) A medical prosthesis as recited in claim 1, wherein the second polymer comprises the tyrosine-derived polyarylate and chitosan and the first polymer is hydrophilic and comprises chitosan. ### Claim 6 (depends on 1) A medical prosthesis as recited in claim 1, wherein the second polymer comprises the tyrosine-derived polyarylate and cellulose and the first polymer is hydrophilic and comprises chitosan. ### Claim 7 (depends on 1) A medical prosthesis as recited in claim 1, wherein the second polymer comprises the tyrosine-derived polyarylate and a mixture of rifampin and minocycline and the first polymer is hydrophilic and comprises chitosan. ### Claim 8 (depends on 1) A medical prosthesis as recited in claim 1, wherein the second polymer comprises the tyrosine-derived polyarylate and the first polymer comprises PEG and chitosan. ### Claim 9 (depends on 1) A medical prosthesis as recited in claim 1, wherein the second polymer comprises the tyrosine-derived polyarylate and chitosan and the first polymer comprises PEG and chitosan. ### Claim 10 (depends on 1) A medical prosthesis as recited in claim 1, wherein the second polymer comprises the tyrosine-derived polyarylate and cellulose and the first polymer comprises PEG and chitosan. ### Claim 11 (depends on 1) A medical prosthesis as recited in claim 1, wherein the second polymer comprises the tyrosine-derived polyarylate and a mixture of rifampin and minocycline and the first polymer comprises PEG and chitosan. ### Claim 12 (depends on 1) A medical prosthesis as recited in claim 1, wherein the second polymer comprises the tyrosine-derived polyarylate and the first polymer comprises collagen and chitosan. ### Claim 13 (depends on 1) A medical prosthesis as recited in claim 1, wherein the second polymer comprises the tyrosine-derived polyarylate and chitosan and the first polymer comprises collagen and chitosan. ### Claim 14 (depends on 1) A medical prosthesis as recited in claim 1, wherein the second polymer comprises the tyrosine-derived polyarylate and cellulose and the first polymer comprises collagen and chitosan. ### Claim 15 (depends on 1) A medical prosthesis as recited in claim 1, wherein the second polymer comprises the tyrosine-derived polyarylate and a mixture of rifampin and minocycline and the first polymer comprises collagen and chitosan. ### Claim 16 A medical prosthesis comprising: a surgical mesh with a coating, the coating including a first layer and a second layer, the first layer being positioned between the mesh and the second layer, wherein the coating is applied to the mesh without substantially altering a porosity of the mesh, wherein the first layer comprises a first polymer and the second layer comprises a second polymer that is different than the first polymer, and wherein at least one of the polymers comprises a tyrosine-derived polyarylate and a mixture of rifampin and minocycline.