# US 10,765,398 B1 · Apparatus and method for measuring the sound transmission characteristics of the central nervous system volume of humans

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- Number: US 10,765,398 B1
- Document ID: US10765398B1
- Status: Granted
- Kind: B1
- Application number: 15/960,837
- Filed: 2018-04-24
- Granted: 2020-09-08
- Earliest claimed: 2013-09-06
- Applicants: John William Millard; Curtis Lane Prichard
- Inventors: John William Millard; Curtis Lane Prichard
- Web page: https://patentgrep.com/patent/US10765398B1

## CPC

- A61B 7/006: {Detecting skeletal, cartilage or muscle noise (A61B7/003 and A61B7/008 take precedence)}
- A61B 8/08: Clinical applications (A61B8/02, A61B8/04, A61B8/06 take precedence)
- A61B 8/5223: {for extracting a diagnostic or physiological parameter from medical diagnostic data (for algorithms to analyse biomedical images G06T7/0012)}
- G16H 50/30: for calculating health indices; for individual health risk assessment
- A61B 5/032: {Spinal fluid pressure}
- A61B 5/14507: {specially adapted for measuring characteristics of body fluids other than blood (devices for taking samples of body liquids A61B10/0045)}
- A61B 5/4064: {Evaluating the brain (for intracranial pressure A61B5/031; for cerebral blood gases A61B5/14553; using EEG A61B5/369)}
- A61B 8/0808: {for diagnosis of the brain}
- A61B 8/0875: {for diagnosis of bone}
- A61B 8/15: Transmission-tomography
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

An apparatus for detecting the presence of pathogens in cerebrospinal fluid (CSF) within the central nervous system (CNS) includes a digital computer, a speaker unit and a microphone unit. The digital computer is programmed with generally available software which is capable of generating a spectrum of sound and receiving microphone data. The software is able to receive microphone signals and represent resulting data in graphical form showing sound intensity in dB as a function of frequency in kHz. An operator places the speaker and the microphone on the subject's body so that sound travels through at least a portion of the CNS, runs the software, and collects the resulting sound propagation data. If the propagation of sound through the CNS is indicative of altered CSF or CNS, then a disease state is suspected.

## Claims

### Claim 1

A method for analyzing the sound transmission characteristics of the volume occupied by the central nervous system of a human, comprising the following steps:
(a) obtaining a digital computer and a speaker and a microphone which interface with that computer,
(b) programming the digital computer with a computer program which is capable of (i) generating a spectrum of sounds for output through the speaker which ranges between pre-selected low frequency and a pre-selected high frequency and transmitting that sound to the speaker, (ii) receiving data from the microphone during the sound output of step (b) (i) and analyzing that data to determine the frequency of the sound detected by the microphone and its intensity in decibels such that sounds ranging between the low frequency and the high frequency are detected and measured for both frequency and intensity and (iii) generating an output showing the sound received by the microphone in terms of sound intensity in decibels as a function of sound frequency,
(c) running the program of the digital computer of step (b) while placing the speaker and the microphone in a spaced apart relationship on the surface of the back of a human test subject proximate to the spinal column,
(d) analyzing the output of the computer program of step (b) to determine if the sound propagation characteristics of the volume occupied by the central nervous system of the test subject are normal in a way that substantially rules out an abnormal condition or disease state or abnormal in a way that may indicate an abnormal condition or disease state.

### Claim 2 (depends on 1)

The method of claim 1, wherein,
the frequency range generated by the speaker is between 100 Hz and 1500 Hz and the frequency range received by the microphone and analyzed by the software is between 10 Hz and 20 k Hz.

### Claim 3 (depends on 1)

The method of claim 1, wherein,
the frequency range generated by the speaker is between 100 Hz and 1500 Hz and the frequency range received by the microphone and analyzed by the software is between 10 Hz and 20 k Hz.