# US 10,765,361 B2 · Automated sequential injection and blood draw

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,765,361 B2
- Document ID: US10765361B2
- Status: Granted
- Kind: B2
- Application number: 14/635,580
- Filed: 2015-03-02
- Published: 2016-09-08
- Granted: 2020-09-08
- Earliest claimed: 2015-03-02
- Assignees: Verily Life Sciences LLC
- Applicants: Verily Life Sciences LLC
- Inventors: Benjamin David Krasnow; Eric Peeters; Peter Howard Smith
- Web page: https://patentgrep.com/patent/US10765361B2

## CPC

- A61B 5/4839: {combined with drug delivery}
- A61B 5/1411: {by percutaneous method, e.g. by lancet}
- A61B 5/1455: using optical sensors, e.g. spectral photometrical oximeters
- A61B 5/150022: {for capillary blood or interstitial fluid}
- A61B 5/150068: {by tissue compression, e.g. with specially designed surface of device contacting the skin area to be pierced}
- A61B 5/150099: {by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes}
- A61B 5/150236: {Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood}
- A61B 5/150343: {Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes (sampling from within body cavities A61B5/150015, A61B5/150045)}
- A61B 5/150389: {Hollow piercing elements, e.g. canulas, needles, for piercing the skin}
- A61B 5/150519: {Details of construction of hub, i.e. element used to attach the single-ended needle to a piercing device or sampling device}
- A61B 5/150572: {Pierceable protectors, e.g. shields, caps, sleeves or films, e.g. for hygienic purposes}
- A61B 5/150854: {long distance, e.g. between patient's home and doctor's office}
- A61B 5/150969: {Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing}
- A61B 5/15109: {Fully automatically triggered, i.e. the triggering does not require a deliberate action by the user, e.g. by contact with the patient's skin}
- A61B 5/15125: {comprising a vacuum or compressed fluids}
- A61B 5/1513: {comprising linear sliding guides (comprising tooth-shaped elements A61B5/15132)}
- A61B 5/1519: {comprising driving means, e.g. a spring, for propelling the piercing unit}
- A61B 5/15194: {fully automatically retracted, i.e. the retraction does not require a deliberate action by the user, e.g. by terminating the contact with the patient's skin}
- A61B 5/155: {Devices} specially adapted for continuous or multiple sampling, e.g. at predetermined intervals {(devices loaded with multiple lancets simultaneously A61B5/15146)}
- A61B 5/157: {Devices} characterised by integrated means for measuring characteristics of blood
- A61B 5/681: {Wristwatch-type devices}
- A61B 5/686: {Permanently implanted devices, e.g. pacemakers, other stimulators, biochips (A61B5/6861 takes precedence)}
- A61B 17/3468: {for implanting or removing devices, e.g. prostheses, implants, seeds, wires (devices for implanting seeds A61M37/0069)}
- A61M 5/007: {for contrast media}
- A61M 5/20: Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically (A61M5/142 takes precedence)
- A61M 5/2033: {Spring-loaded one-shot injectors with or without automatic needle insertion (multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287)}
- A61M 5/2046: {Media being expelled from injector by gas generation, e.g. explosive charge}
- A61M 5/2053: {Media being expelled from injector by pressurised fluid or vacuum (for infusion A61M5/145, A61M5/155)}
- A61M 5/3287: {Accessories for bringing the needle into the body; Automatic needle insertion (A61M5/20, A61M5/31525 take precedence)}
- A61M 5/206: {with automatic needle insertion}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

Devices are provided to automatically inject drugs or other payloads into or beneath skin. These devices include an injector configured to drive a hollow needle into the skin and subsequently to deliver the payload through the hollow needle. Applied suction acts to draw blood from the puncture formed in the skin through the hollow needle, into the device, and to a sensor, blood storage element, or other payload. In some examples, the blood is drawn through the hollow needle when the hollow needle is penetrating the skin. In some examples, these devices are additionally configured to retract the hollow needle from the skin and/or to perform some other functions. These devices can be wearable and configured to automatically access blood or deliver a payload into skin, for example, to operate at one or more points in time while a wearer of a device is sleeping.

## Claims

### Claim 1

A system comprising:
a housing;
a seal disposed on a surface of the housing;
a first chamber disposed within the housing, wherein the first chamber contains a sealant layer;
a hollow needle disposed in the first chamber and configured to pierce the sealant layer, wherein the hollow needle comprises a first channel;
a reservoir, wherein the reservoir contains a payload;
an injector, wherein the injector is operable to drive the hollow needle through the seal to form a hole in the seal and thereafter into skin to form a puncture in the skin, such that the payload is delivered from the reservoir into the skin via the first channel;
a second chamber disposed within the housing;
a second channel coupled to the second chamber, wherein the second channel is formed by the seal and the housing;
a suction source configured to provide suction, wherein the suction provided by the suction source is configured to draw blood from the puncture formed in the skin into the second chamber via the hole formed in the seal and the second channel;
a sensor; and
a controller, wherein the controller is configured to perform controller functions including:
operating the sensor to detect information about an environment of the system;
determining that a specified condition has occurred based on the information about the environment of the system detected using the sensor; and
responsive to determining that the specified condition has occurred, operating the injector to drive the hollow needle through the seal and into the skin to deliver the payload into the skin via the first channel.

### Claim 2 (depends on 1)

The system of claim 1, wherein the injector comprises:
a piston disposed in the first chamber, wherein the hollow needle is coupled to the piston, wherein the piston comprises the reservoir, and wherein the piston is configured to slidably move within the first chamber; and
a propellant, wherein the propellant is configured to slidably move the piston within the first chamber to drive the hollow needle through the seal and into skin.

### Claim 3 (depends on 1)

The system of claim 1, wherein the seal comprises a concave depression, wherein the injector is configured to drive the hollow needle into skin proximate the concave depression, and wherein the suction provided by the suction source is configured to suction the skin into the concave depression.

### Claim 4 (depends on 1)

The system of claim 1, wherein the sensor is disposed in the second channel, and wherein the sensor is configured to detect a property of blood to which the sensor is exposed.

### Claim 5 (depends on 1)

The system of claim 1, wherein the payload contained by the reservoir comprises heparin.

### Claim 6 (depends on 1)

The system of claim 1, wherein determining that a specified condition has occurred comprises determining that a specified point in time has been reached.

### Claim 7 (depends on 1)

The system of claim 1, wherein the suction source comprises an evacuated volume in the second chamber.

### Claim 8 (depends on 1)

The system of claim 1, further comprising a spring disposed within the first chamber, wherein the spring is configured to retract the hollow needle from the skin.