# US 10,765,349 B2 · Magnetic resonance imaging device and method for calculating oxygen extraction fractions > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,765,349 B2 - Document ID: US10765349B2 - Status: Granted - Kind: B2 - Application number: 16/342,612 - Filed: 2017-10-11 - Published: 2019-08-29 - Granted: 2020-09-08 - Earliest claimed: 2016-11-07 - Assignees: Hitachi, Ltd. - Applicants: Hitachi, Ltd. - Inventors: Toru Shirai; Ryota Satoh; Yo Taniguchi; Hisaaki Ochi; Yoshihisa Sotome; Yoshitaka Bito; Takenori Murase - Web page: https://patentgrep.com/patent/US10765349B2 ## CPC - A61B 5/14542: {for measuring blood gases (A61B5/14551 takes precedence)} - A61B 5/0042: {for the brain} - A61B 5/055: involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging - A61B 5/14551: {for measuring blood gases} - G01R 33/443: {Assessment of an electric or a magnetic field, e.g. spatial mapping, determination of a B0 drift or dosimetry} - G01R 33/543: {Control of the operation of the MR system, e.g. setting of acquisition parameters prior to or during MR data acquisition, dynamic shimming, use of one or more scout images for scan plane prescription (G01R33/546 takes precedence)} - G01R 33/5602: {by filtering or weighting based on different relaxation times within the sample, e.g. T1 weighting using an inversion pulse} - G01R 33/5608: {Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels (image data processing or generation, in general G06T)} - G06T 1/00: General purpose image data processing - G01N 24/08: by using nuclear magnetic resonance (G01N24/12 takes precedence) - G01R 33/4824: {using a non-Cartesian trajectory} - G01R 33/50: based on the determination of relaxation times {, e.g. T1 measurement by IR sequences; T2 measurement by multiple-echo sequences} - G01R 33/5616: {using gradient refocusing, e.g. EPI} - G01R 33/5617: {using RF refocusing, e.g. RARE} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12) - G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract Provided is a technique for calculating an oxygen extraction fraction by using MRI where the oxygen extraction fraction in a brain including brain parenchyma is calculated via a simple processing without an impact on an examinee, such as administration of caffeine. For this purpose, an MRI apparatus of the present invention measures a complex image of nuclear magnetic resonance signals, and calculates from thus measured complex image, a physical property distribution for obtaining a physical property image reflecting the oxygen extraction fraction. Then, thus calculated physical property distribution is separated into tissue-specific physical property distributions for at least two tissues (separated tissue images). After converting any of the separated tissue images into the oxygen extraction fraction, a distribution of the oxygen extraction fraction is estimated based on the condition that a value of any selected pixel is substantially equal to a mean value of pixels surrounding the selected pixel. ## Claims ### Claim 1 A magnetic resonance imaging apparatus comprising, a measuring unit having a transmitter configured to transmit an RF magnetic field pulse to a subject placed in a static magnetic field, a receiver configured to receive a nuclear magnetic resonance signal generated from the subject, and a gradient magnetic field generator configured to provide the static magnetic field with a gradient magnetic field, a measurement controller configured to control an operation of the measuring unit, according to an imaging sequence being preset, and a computer configured to perform computation on the nuclear magnetic resonance signal being received, wherein, the computer comprises, an image reconstructor configured to generate a complex image from the nuclear magnetic resonance signal acquired at least one echo time, a physical property distribution calculator configured to calculate a physical property image, having as a pixel value, a physical property reflecting oxygen content characteristics, a tissue separator configured to separate the physical property image of a target area into tissue-specific physical property images of at least two types of tissue, and to calculate separated tissue images, an oxygen content characteristics converter configured to convert the physical property of each pixel into the oxygen content characteristics, as to at least one of the separated tissue images, and an oxygen content characteristics distribution estimator configured to estimate a distribution of the oxygen content characteristics in the target area, based on a condition that a value of any pixel is equal to a mean value of surrounding pixels, in the separated tissue image after converting the pixel value into the oxygen content characteristics. ### Claim 2 (depends on 1) The magnetic resonance imaging apparatus according to claim 1, wherein, the physical property distribution calculator comprises a susceptibility distribution calculator configured to calculate a susceptibility distribution from phase information of the complex image. ### Claim 3 (depends on 1) The magnetic resonance imaging apparatus according to claim 1, wherein, the measurement controller controls the measuring unit by using an imaging sequence for acquiring nuclear magnetic resonance signals at different echo times at least two, and the physical property distribution calculator comprises an R2* distribution calculator configured to calculate a distribution of an apparent transverse relaxation rate R2*, from intensity information of the complex images acquired at multiple different echo times. ### Claim 4 (depends on 1) The magnetic resonance imaging apparatus according to claim 1, wherein, the tissue separator separates veins from the other tissues. ### Claim 5 (depends on 4) The magnetic resonance imaging apparatus according to claim 4, wherein, the oxygen content characteristics distribution estimator configured to estimate the distribution of the oxygen content characteristics in the target area, on the basis of a first condition that a value of any selected pixel indicating the oxygen content characteristics of a brain tissue is substantially equal to a mean value of pixels surrounding the selected pixel, and a second condition that the mean value of pixels surrounding the selected pixel indicating the oxygen content characteristics of the brain tissue is substantially equal to a mean value of pixels surrounding the selected pixel indicating the oxygen content characteristics of veins. ### Claim 6 (depends on 1) The magnetic resonance imaging apparatus according to claim 1, wherein, the tissue separator separates brain parenchyma from the other tissues. ### Claim 7 (depends on 1) The magnetic resonance imaging apparatus according to claim 1, wherein, the oxygen content characteristics distribution estimator comprises a partial volume effect corrector configured to correct a partial volume effect, on the basis of the condition that the oxygen content characteristics of any tissue is substantially equal to a mean value of the oxygen content characteristics of a whole brain. ### Claim 8 (depends on 1) The magnetic resonance imaging apparatus according to claim 1, wherein, the oxygen content characteristics estimated by the oxygen content characteristics distribution estimator includes any of an oxygen extraction fraction, oxygen saturation, and a metabolic rate of oxygen. ### Claim 9 (depends on 1) The magnetic resonance imaging apparatus according to claim 1, wherein, the tissue separator separates an image of any selected tissue, by using a morphology filter that separates an original image into a particulate component image, a vascular component image, and a smoothed image. ### Claim 10 A method of calculating an oxygen extraction fraction in a test subject by using measurement data acquired by imaging through an MRI apparatus, comprising, reconstructing an image from a complex image of the test subject by using the measurement data, calculating a susceptibility distribution by using the complex image, separating the susceptibility distribution into tissue-specific susceptibility distributions of a plurality of tissues to obtain separated tissue images, and estimating the oxygen extraction fraction in the test subject from the tissue-specific susceptibility distributions, as to at least one of the separated tissue images, under the assumption that a magnetic susceptibility of any pixel is equal to the magnetic susceptibility in an area having a predetermined size surrounding the pixel. ### Claim 11 (depends on 10) The method of calculating the oxygen extraction fraction according to claim 10, wherein, the oxygen extraction fraction estimated from the separated tissue image is further subjected to a partial volume effect correction, based on a condition that the oxygen extraction fraction in any tissue is substantially equal to a mean value of the oxygen extraction fraction in a whole brain. ### Claim 12 (depends on 10) The method according to either claim 10, the plurality of tissues includes brain veins and brain parenchyma. ### Claim 13 A method of calculating an oxygen extraction fraction in a test subject by using measurement data acquired by imaging through an MRI apparatus, comprising, reconstructing a plurality of complex images at different echo times by using the measurement data, calculating a distribution of an apparent transverse relaxation rate R2* or a distribution of a difference between the apparent transverse relaxation rate R2* and a transverse relaxation rate R2, separating the distribution of the apparent transverse relaxation rate R2* or the distribution of the difference, into tissue-specific separated images of a plurality of tissues, and estimating the oxygen extraction fraction in the test subject, from the distribution of the apparent transverse relaxation rate R2* or the distribution of the difference, as to at least one of the separated tissue images, under the assumption that a value of any selected pixel is equal to pixel values in an area having a predetermined size surrounding the selected pixel.