# US 10,765,322 B2 · Fast parallel optical coherence tomographic image generating apparatus and method

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- Number: US 10,765,322 B2
- Document ID: US10765322B2
- Status: Granted
- Kind: B2
- Application number: 16/164,543
- Filed: 2018-10-18
- Published: 2019-04-25
- Granted: 2020-09-08
- Earliest claimed: 2017-10-19
- Assignees: Korea Basic Science Institute
- Applicants: Korea Basic Science Institute
- Inventors: Kye Sung Lee; Ki Soo Chang
- Web page: https://patentgrep.com/patent/US10765322B2

## CPC

- A61B 5/0066: {Optical coherence imaging}
- A61B 3/00: Apparatus for testing the eyes; Instruments for examining the eyes (eye inspection using ultrasonic, sonic or infrasonic waves A61B8/10)
- G01B 9/02034: {characterised by particularly shaped beams or wavefronts}
- G01B 9/02044: {Imaging in the frequency domain, e.g. by using a spectrometer}
- G01B 9/02083: {characterised by particular signal processing and presentation}
- G01B 9/02091: Tomographic interferometers, e.g. based on optical coherence
- A61B 3/102: {for optical coherence tomography [OCT]}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G01B: MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS

## Abstract

Provided is a fast parallel optical coherence tomographic image generating method including dispersing light into N spectral regions Δλ1 through ΔλN sequentially from a low frequency wavelength to a high frequency wavelength, the light being emitted from a broadband light source of a fast parallel optical coherence tomographic image generating apparatus, N being an integer greater than or equal to 2, splitting the light emitted from the broadband light source to be incident on a sample and a reference mirror, partitioning the sample into N image regions P1 through PN, discretely controlling a beam scanner such that the light emitted from the broadband light source is incident on the sample at a position changed by a preset distance, acquiring an interference spectral image through interference light formed in response to interference of measurement light and reference light, and generating a tomographic image of the sample using the interference spectral image.

## Claims

### Claim 1

A fast parallel optical coherence tomographic image generating method comprising:
dispersing light into N spectral regions Δλ1 through ΔλN sequentially from a low frequency wavelength to a high frequency wavelength, the light being emitted from a broadband light source of a fast parallel optical coherence tomographic image generating apparatus, N being an integer greater than or equal to 2;
splitting the light emitted from the broadband light source to be incident on a sample and a reference mirror;
partitioning the sample into N image regions P1 through PN;
discretely controlling a beam scanner such that the light emitted from the broadband light source is incident on the sample at a position changed by a preset distance;
acquiring an interference spectral image through interference light formed in response to interference of measurement light and reference light, the measurement light being light corresponding to at least two of the N spectral regions and being reflected from the sample and the reference light being light corresponding to the at least two spectral regions and being reflected from the reference mirror; and
generating a tomographic image of the sample using the interference spectral image,
wherein the N spectral regions are incident on the sample at the same spectral distance which is a physical width, and a distance between the N image regions of the sample is equal to the spectral distance,
wherein the preset distance is expressed by a product of the spectral distance and a number of image regions to be skipped by an end portion of the light radiated on the sample for each step among the N image regions,
wherein in the discretely controlling, an overall distance the light is to be moved by the beam scanner along a single line is calculated according to:
D=2(N×x)−2(n×w), and
wherein, D is the overall distance, N is a number of the image regions, n is the number of image regions to be skipped by the end portion of the light radiated on the sample for each step, and w is the spectral distance.

### Claim 2 (depends on 1)

The fast parallel optical coherence tomographic image generating method of claim 1, wherein the discretely controlling comprises:
determining whether a distance the radiated light is moved by the beam scanner is greater than the overall distance;
moving the radiated light to an initial position of a subsequent line, if the distance the radiated light is moved is greater than the overall distance; and
moving the radiated light the preset distance, if the distance the radiated light is moved is less than the overall distance.

### Claim 3 (depends on 1)

The fast parallel optical coherence tomographic image generating method of claim 1, wherein the generating comprises dividing the interference spectral image into N regions by wavelength and inputting the N regions into respective pixels of a line scan camera.

### Claim 4 (depends on 3)

The fast parallel optical coherence tomographic image generating method of claim 3, wherein a number of the pixels of the line scan camera is greater than or equal to N, and
the N regions into which the interference spectral image is divided are incident on the respective pixels of the line scan camera.

### Claim 5 (depends on 1)

The fast parallel optical coherence tomographic image generating method of claim 1, wherein the fast parallel optical coherence tomographic image generating apparatus comprises an object lens configured to receive light reflected from the beam scanner, and has a common optical path from the broadband light source to the object lens.

### Claim 6 (depends on 5)

The fast parallel optical coherence tomographic image generating method of claim 5, wherein the fast parallel optical coherence tomographic image generating apparatus further comprises:
a split window disposed between the object lens and the sample, the split window including a beam splitter configured to reflect light incident from the object lens toward the reference mirror.

### Claim 7 (depends on 6)

The fast parallel optical coherence tomographic image generating method of claim 6, wherein the fast parallel optical coherence tomographic image generating apparatus further comprises:
a first compensation window disposed between the split window and the reference mirror, the first compensation window having a greater thickness than the split window so as to compensate for a difference in optical path of the reference light.

### Claim 8 (depends on 7)

The fast parallel optical coherence tomographic image generating method of claim 7, wherein the fast parallel optical coherence tomographic image generating apparatus further comprises:
a cover glass positioned between the split window and the sample; and
a second compensation window disposed between the first compensation window and the reference mirror, the second compensation window and the cover glass having the same thickness so as to compensate for a difference in optical path of the reference light.

### Claim 9 (depends on 5)

The fast parallel optical coherence tomographic image generating method of claim 5, wherein the fast parallel optical coherence tomographic image generating apparatus further comprises:
a cube-type split window disposed between the object lens and the sample, the cube-type split window including a beam splitter configured to reflect light incident from the object lens toward the reference mirror, the cube-type split window having a symmetrical shape with respect to the beam splitter.
