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US 10,761,100 B2Granted
Systems, assays, and methods for determining risk factors for Alzheimer's disease
AssigneeBrigham Young University
InventorsSteven W. Graves, John S. K. Kauwe, III
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Abstract
A method of determining risk factors for Alzheimer's disease in an individual, including assaying a biological medium obtained from the individual for a biomarker selected from Biomarker 1, Biomarker 2, Biomarker 3, or Biomarker 4, where Biomarker 1 has a mass-to-charge ratio (m/z) of 602.3, Biomarker 2 has a m/z of 804.6, Biomarker 3 has a m/z of 874.6, and Biomarker 4 has a m/z of 804.5, and where the presence of the two or more biomarkers in the individual indicates a risk factor of Alzheimer's disease.
Claims9
A method comprising:
- assaying a biological medium to determine the presence of a biomarker selected from the group consisting of Biomarker 1, Biomarker 2, Biomarker 3, Biomarker 4, and combinations thereof;
- wherein Biomarker 1 is a peptide having an amino acid sequence L/IAENR (SEQ ID NO:
- 001) and has a mass-to-charge ratio (m/z) of 602.3 at a charge state of 1, Biomarker 2 has a molecular formula of [C46H78NO8P]+H+ and has a m/z of 804.6 at a charge state of 1, Biomarker 3 has a molecular formula of [C46H84NO12P]+H+ and has a m/z of 874.6 at a charge state of 1, and Biomarker 4 has a molecular formula of [C42H78NO11P+H+] and has a m/z of 804.5 at a charge state of 1, and wherein the presence of the biomarkers in the individual indicates the presence of Alzheimer's disease;
- and
- administering a treatment for Alzheimer's disease to the individual.
2 more elements
Dependencies are inferred from the claim text.