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US 10,761,099 B2Granted
Compositions and methods for treatment of lung function
AssigneeChildren's Hospital Medical Center
InventorsAssem Ziady, Rhonda Szczesniak, John Clancy, Cole Brokamp
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Abstract
Disclosed herein are methods for detecting protein expression in an individual diagnosed with cystic fibrosis. The methods, in certain aspects, include the steps of obtaining a sample from said individual and detecting expression in said sample of each protein of a protein set. The method may further include the step of determining expression level of one or more proteins of the protein set. The disclosed methods may be used to predict one or more clinical parameters in an individual having cystic fibrosis.
Claims15
A treatment method comprising:
- a. detecting expression of each protein of a protein set in a sample from an individual diagnosed with cystic fibrosis (CF), wherein said protein set comprises one or more proteins selected from glutamate receptor 2, uridine-cytidine kinase-like 1, chromosome 12 ORF 42, or keratin 18 (KRT18);
- b. obtaining a risk probability score based on the expression level of said protein set of step a;
- and
- c. treating said individual with one or both of an anti-inflammatory and an anti-bacterial based on said risk probability score.
1 more element
A treatment method comprising
- a. calculating a risk probability score from expression levels of a protein set from a sample obtained from an individual diagnosed with Cystic Fibrosis, wherein said protein set comprises one or more proteins selected from glutamate receptor 2, uridine-cytidine kinase-like 1, chromosome 12 ORF 42, or keratin 18 (KRT18);
- and
- b. forecasting lung function trajectory based on said risk probability score;
- and
- c. treating said individual with one or both of an anti-inflammatory and an anti-bacterial based on said risk probability score;
- wherein one or both of step (a) and step (b) are performed on a computer.
3 more elements
Dependencies are inferred from the claim text.