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US 10,761,098 B2Granted
Methods and tools for Vel blood group typing
AssigneeLU License AB
InventorsJill R. Storry, Magnus Jöud, Björn Nilsson, Martin L. Olsson
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Abstract
The present invention relates to methods and tools for discriminating between Vel negative and Vel positive phenotypes. The invention is thus useful for determining Vel blood group status of individuals about to receive blood transfusion.
Claims16
A method of detecting an anti-Vel antibody in a sample obtained from a subject to determine the blood type of the subject, which comprises:
- a) contacting the sample with an antigen consisting of a fragment of at least 5 consecutive amino acid residues and at most 25 consecutive amino acid residues of a polypeptide having at least 87% identity to SEQ ID NO:
- 5, and
- b) detecting an antigen/antibody complex, whereby detection of the antigen/antibody complex indicates the presence of the anti-Vel antibody.
Dependencies are inferred from the claim text.