Artifact compensation due to different properties of fluid accommodation volumes in sample separation apparatus
AssigneeAgilent Technologies, Inc.
InventorsDwight Robert Stoll, Konstantin Shoykhet, Klaus Witt, Stephan Buckenmaier
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Abstract
A control device for controlling at least part of a sample separation apparatus for separating a fluidic sample, the sample separation apparatus including at least two fluid accommodation volumes having different flow through properties and each being configured for temporarily accommodating fluidic sample, wherein the control device is configured for controlling operation of at least part of the sample separation apparatus for at least partially compensating sample separation artifacts resulting from the different flow through properties of the fluid accommodation volumes.
Claims20
A control device for controlling at least part of a sample separation apparatus for separating a fluidic sample, the sample separation apparatus comprising:
- at least two fluid accommodation volumes in fluid communication with a source of the fluidic sample, the at least two fluid accommodation volumes having different flow through properties and each being configured to receive the fluidic sample and temporarily accommodate the fluidic sample, wherein the fluidic sample in each of the at least two fluid accommodation volumes comprises a plurality of fractions to be separated by a separation unit of the sample separation apparatus, and
- wherein the control device is at least programmed to control an operation of the sample separation apparatus comprising:
- at least partially compensating for sample separation artifacts contained in sample separation result data obtained from the separated sample, the sample separation artifacts resulting from the different flow through properties of the at least two fluid accommodation volumes, by, in accordance with the different flow through properties, adjusting a timing of a start and/or an end of introducing the fluidic sample from at least part of the at least two fluid accommodation volumes into a flow path towards the separation unit.
A control device for controlling at least part of a sample separation apparatus for separating a fluidic sample, the sample separation apparatus comprising:
- at least two fluid accommodation volumes in fluid communication with a source of the fluidic sample, the at least two fluid accommodation volumes having different flow through properties and each being configured to receive the fluidic sample and temporarily accommodate the fluidic sample, wherein the fluidic sample in each of the at least two fluid accommodation volumes comprises a plurality of fractions to be separated by a separation unit of the sample separation apparatus, and
- wherein the control device is at least programmed to control an operation of the sample separation apparatus comprising:
- at least partially compensating for sample separation artifacts contained in sample separation result data obtained from the separated sample, the sample separation artifacts resulting from the different flow through properties of the at least two fluid accommodation volumes, by, in accordance with the different flow through properties, recalculating the sample separation result data.
A method of controlling at least part of a sample separation apparatus for separating a fluidic sample, the sample separation apparatus comprising at least two fluid accommodation volumes in fluid communication with a source of the fluidic sample, the at least two fluid accommodation volumes having different flow through properties and each being configured for receiving the fluidic sample and temporarily accommodating the fluidic sample, wherein the fluidic sample in each of the at least two fluid accommodation volumes comprises a plurality of fractions to be separated by a separation unit of the sample separation apparatus, the method comprising:
- controlling an operation of the sample separation apparatus to at least partially compensate for sample separation artifacts contained in sample separation result data obtained from the separated sample, the sample separation artifacts resulting from the different flow through properties of the at least two fluid accommodation volumes by, in accordance with the different flow through properties, adjusting a timing of a start and/or an end of introducing the fluidic sample from at least part of the at least two fluid accommodation volumes into a flow path towards the separation unit.
Dependencies are inferred from the claim text.