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US 10,761,053 B2Granted
Non-enzymatic electrochemical sensor for measuring analytes
AssigneeTerumo Kabushiki Kaisha
InventorJeff T. Suri
Life of this patent
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Abstract
Embodiments described herein relate generally to compositions that include a synthetic redox-active receptor, and in particular to compositions that include a boronic acid based synthetic redox-active receptor which can electrochemically sense a target analyte in a sample solution. In some embodiments, a synthetic redox-active receptor can have a composition of formula I: wherein the variables L, L′, R, R′, n and X− are described herein.
Claims10
An electrochemical sensing system, comprising:
- a working electrode;
- a composition disposed on the working electrode;
- a reference electrode;
- an electrical circuit electronically coupled to the working electrode and the reference electrode, the electrical circuit configured to measure a current or voltage corresponding to a concentration of a target analyte;
- wherein the composition comprises a salt of formula (Va):
- where:
- X− is an anion;
- L and L′ are independently H, halogen, OH, CN, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, alkylthio, arylthio, alkoxy, aryloxy, —COOR4, NH2, —C(O)N(H)—(CH2)p—N(H)C(O)—R4, —C(O)NH(R4), or —N(H)C(O)R4;
- R4 is independently at each occurrence H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, aryl, heteroaryl, heterocyclyl, or cycloalkyl;
- n is 2, 3, 4, 5, or 6;
- and
- p is independently 0, 1, 2, 3, 4, 5, or 6.
9 more elements
An electrochemical sensing system, comprising:
- a working electrode,
- a composition disposed on the working electrode,
- a reference electrode,
- an electrical circuit electronically coupled to the working electrode and the reference electrode, the electrical circuit configured to measure a current or voltage corresponding to a concentration of a target analyte;
- wherein the composition comprises a compound having the structure:
2 more elements
Dependencies are inferred from the claim text.