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US 10,761,045 B2Granted
Sensor, sensor system, method of manufacturing sensor, and method of measuring concentration of target substance
AssigneePhc Holdings Corporation
InventorsMotonori Uchiyama, Takuo Kouno
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Abstract
The present invention provides: a reagent composition having higher storage stability; a sensor involving the reagent composition; and others. According to the present invention, a specific heterocyclic compound is added to a reagent composition to improve the storage stability of the reagent composition and reduce the degree of fluctuation in current values in a sensor that utilizes reagent composition.
Claims6
A sensor comprising:
- at least one pair of electrodes;
- and
- a reagent layer being in contact with at least a part of one of the pair of electrodes,
- wherein the reagent layer comprises:
- a FAD-dependent glucose dehydrogenase;
- a quinone or a quinone derivative as an electron acceptor;
- and
- a heterocyclic compound represented by one of the following general formulae (I-1) to (I-5):
- wherein:
- R1 represents a hydrogen atom;
- R2 to R5, if present, each independently represent a hydrogen atom, an amino group, a hydroxyl group, or a C1-12 hydrocarbon group;
- the C1-12 hydrocarbon group may have at least one substituent selected from the group consisting of an amino group, a hydroxyl group, and a carboxyl group;
- at least one of R2 to R5 of the heterocyclic compound is an amino group;
- and
- the heterocyclic compound is not histidine or histamine.
12 more elements
A sensor comprising:
- at least one pair of electrodes;
- and
- a reagent layer being in contact with at least a part of one of the pair of electrodes,
- wherein the reagent layer comprises:
- a FAD-dependent glucose dehydrogenase;
- a quinone or a quinone derivative as an electron acceptor;
- and
- a heterocyclic compound,
- wherein the heterocyclic compound is at least one compound selected from the group consisting of 2-amino-imidazole, 4,5-bis(hydroxymethyl)imidazole, 2-methylimidazole, 1,2-dimethylimidazole, 3-amino-1,2,4-triazole, 4-amino-1,2,4-triazole, and 3,5-diamino-1,2,4-triazole.
6 more elements
Dependencies are inferred from the claim text.