Transformed fungus having enhanced ergothioneine productivity and method for producing ergothioneine
AssigneeKikkoman Corporation
InventorsSeiichi Hara, Keiko Kurosawa, Keiichi Ichikawa
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AssigneeKikkoman Corporation
InventorsSeiichi Hara, Keiko Kurosawa, Keiichi Ichikawa
Estimating the term…
The purpose of the present invention is to provide an organism having an ergothioneine productivity that is capable of easily producing ergothioneine within a short period of time at a high yield, as compared with a conventional technology, and, therefore, enables ergothioneine production on an industrial scale. This purpose can be achieved by a transformed fungus into which a gene encoding enzyme (1) or genes encoding enzymes (1) and (2) have been inserted and in which the inserted gene(s) are overexpressed. (1) an enzyme catalyzing a reaction of synthesizing hercynyl cysteine sulfoxide from histidine and cysteine in the presence of S-adenosyl methionine, iron (II) and oxygen. (2) An enzyme catalyzing a reaction of synthesizing ergothioneine from hercynyl cysteine sulfoxide using pyridoxal 5′-phosphate as a coenzyme.
A transformed filamentous fungus comprising a gene encoding an enzyme (1) or genes encoding enzymes (1) and (2) inserted therein and can overexpress the inserted gene or genes,
Dependencies are inferred from the claim text.