Human type 55 replication defective adenovirus vector, method for preparing same and uses thereof
AssigneeGuangzhou N Biomed Co., Ltd.
InventorsLing Chen, Liqiang Feng
Life of this patent
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Abstract
Provided are a human type 55 replication defective adenovirus vector, a method for preparing the same and uses thereof. The human type 55 replication defective adenovirus vector is prepared by the following method: knocking out E1 and E3 genes from Ad55, substituting the open reading frame 6 or the open reading frames 2, 3, 4, 6, and 6/7 of E4 gene in Ad55 genome with the corresponding open reading frames of Ad5 genome. In addition, an exogenous gene expression cassette may also be integrated into the E1 gene region of Ad55.
Claims16
A human type 55 replication defective adenovirus vector, comprising type 55 adenovirus (Ad55) genome, wherein:
- E1 and E3 genes of Ad55 are knocked out from the Ad55 genome, and
- open reading frames 2, 3, 4, 5 and 6 of E4 gene in the Ad55 genome are substituted with corresponding open reading frames of type 5 adenovirus (Ad5) genome.
Dependencies are inferred from the claim text.