Process of forming 2-(4-isobutyl-2-methylphenyl) propanal
AssigneeGivaudan SA
InventorsTse Chi-Lam, Martin Alan Lovchik, Simon Ellwood, Andreas Goeke
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Abstract
The regio-selective functionalization of a dialkyl benzene compound wherein the ratio of the compound functionalized at position (a) to the compound functionalized at the position (b) is at least 70:30, more particularly at least 80:20, still more particularly at least 85:15, and still more particularly at least 90:10, characterised in that the substituent R is an isobutyl group.
Claims13
A process of regio-selective functionalization of a dialkyl benzene compound according to the following formula
- wherein the ratio of the compound functionalized at position (a) to the compound functionalized at the position (b) is at least 70:30, and wherein the substituent R is an isobutyl group,
- wherein the process include a carbonylation reaction which introduces a benzaldehyde functionality into the position (a), and
- wherein the carbonylation reaction is carried out using HF/BF3 and carbon monoxide.
A process of forming a compound according to the following formula (I)
- comprising the step of:
- regio-selectively functionalizing a dialkylbenzene compound
- wherein the ratio of the compound functionalized at position (a) to the compound functionalized at the position (b) is at least 70:30, and wherein the substituent R is an isobutyl group.
A process of forming a compound of the following formula (I)
- comprising the steps of:
- —
- and subsequently,
- C) the hydrogenation of compound (VI) to provide compound (I).
A compound of the following formula IIIb
- formed in a process of forming a compound of the following formula (I)
Dependencies are inferred from the claim text.