Process for preparation of isoproterenol hydrochloride
AssigneeEmcure Pharmaceuticals Limited
InventorsMukund Keshav Gurjar, Shashikant Gangaram Joshi, Jagannath Tulsiram Jagtap, Sachin Arvind Badhe
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Abstract
The present invention provides a process for preparation of isoproterenol hydrochloride (1a) comprising catalytic hydrogenation of 3′,4′-dihydroxy-2-(isopropylamino)-acetophenone hydrochloride (5a) in presence of an ion exchange resin, to provide isoproterenol hydrochloride (1a).
Claims10
A process for the preparation of isoproterenol hydrochloride of formula (1a) comprising reacting catechol (2) with chloroacetyl chloride (3) in presence of aluminium chloride to give 2-chloro-3′,4′-dihydroxy acetophenone (4), reacting 2-chloro-3′,4′-dihydroxy acetophenone (4) with isopropyl amine in an organic solvent, treating the reaction product with hydrochloric acid to give 3′,4′-dihydroxy-2-(isopropylamino)-acetophenone hydrochloride (5a), and hydrogenating 3′,4′-dihydroxy-2-(isopropylamino)-acetophenone hydrochloride (5a) in the presence of a resin to provide isoproterenol hydrochloride of formula (1a).
A process for the preparation of isoproterenol hydrochloride of formula (1a) comprising hydrogenating of 3′,4′-dihydroxy-2-(isopropylamino)acetophenone hydrochloride (5a) in presence of a resin to provide isoproterenol hydrochloride of formula (1a).
Dependencies are inferred from the claim text.