VLP stabilized vaccine compositions
AssigneeInventprise, LLC
InventorSubhash V. Kapre
Life of this patent
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Abstract
The invention is directed to compositions and methods for the stabilization of viral and bacterial vaccines. Vaccines of the invention are contained in VLPs with stabilizing agents such as, for example, sugar alcohols (e.g., sorbitol) and degraded gelatins. Preferably the gelatin has an average molecular weight of 10,000 kilodaltons or less. These vaccines have a substantially improved thermostability as well as long term stability. The invention is also directed to the manufacture of a vaccine or the invention and methods for the administration of a vaccine of the invention to patients.
Claims27
A method of treating or preventing an infection comprising:
- determining a therapeutically effective amount of a composition that has been maintained as a liquid to be administered to a mammal in need thereof, wherein:
- the composition comprises virus-like particles (VLPs), an immunogenic component that is protective against the infection and a stabilizing agent,
- the VLP comprises the structural components of hepatitis virus, the immunogenic component comprises a component of human papilloma virus, and the stabilizing agent comprises a degraded gelatin with an average molecular weight of ten kilodaltons or less, and
- the composition has not been maintained in a non-liquid state;
- and
- administering the therapeutically effective amount of the composition to the mammal.
A method of generating an immune response comprising:
- preparing an immunogenic composition that has been maintained as a liquid comprising VLPs, an immunogenic component, and a stabilizing agent, wherein the VLP comprises the structural components of hepatitis virus, the immunogenic component comprises a component of human papilloma virus, and the stabilizing agent comprises a degraded gelatin with an average molecular weight of ten kilodaltons or less, and
- wherein the immunogenic composition has not been maintained in a non-liquid state;
- administering the immunogenic composition to a mammal;
- and
- generating an immune response in the mammal.
A method of generating an immune response against an infectious agent comprising:
- preparing an immunogenic composition as a liquid comprising VLPs, a stabilizing agent, and an immunogenic component, wherein the VLP comprises the structural components of hepatitis virus, the stabilizing agent comprises a degraded gelatin, the immunogenic component comprises a surface antigen of human papilloma virus, and the immunogenic composition does not contain an aluminum compound, and wherein the immunogenic composition has not been maintained in a non-liquid state;
- administering the liquid immunogenic composition to a mammal, wherein the administration does not generate a general inflammatory response or local inflammation at the site of administration;
- and
- generating an immune response against the infectious agent in the mammal.
Dependencies are inferred from the claim text.