Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders
AssigneesCurrax Pharmaceuticals LLC, ProCom One, Inc.
InventorsSusan E. Dubé, Neil B. Kavey
Life of this patent
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Abstract
The invention relates to use of the cis-(Z) isomer or isomeric mixtures containing specified ratios of the cis-(Z) and trans-(E) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders
Claims20
A method for treating insomnia, the method comprising administering an oral formulation comprising doxepin, or a pharmaceutically-acceptable salt thereof, to a patient having a sleep disorder in which, for a given 8 hour period of desired sleep, the patient has difficulty staying asleep during the final 60 minutes of said period, wherein the oral formulation comprises a dosage of doxepin ranging from about 1 to about 7 milligrams, wherein the doxepin or salt is a geometric isomer mixture containing about 18.2% to about 100.0% of the cis-(Z) isomer or is 100% cis (Z) isomer.
Dependencies are inferred from the claim text.