Lattice loss reduction
AssigneeLuye Pharma AG
InventorsLudwig Grader, Holger Piotrowski
Life of this patent
Estimating the term…
Abstract
Methods for producing systems for the transdermal or permucosal administration of active substances and particularly transdermal therapeutic systems (TTS), wherein the active substance depots thereof have a shape that deviates from a rectangular design.
Claims25
A method for producing systems for the transdermal or permucosal administration of active substances, wherein the method comprises the following steps:
- providing a coated carrier film web (10) comprising a carrier film web (1) with an active substance-containing coating (2) adherent thereon, wherein active substance depot areas (12) are defined on the coated carrier film web (10) such that the active substance depot areas (12) are arranged in the web direction (l) of the coated carrier film web (10) in two or more rows such that the proportion of the surface of the coated carrier film web (10) that is not used as active substance depot area (12) by ignoring the rim zones of the coated carrier film web (10) is less than 39% of the total area of the coated carrier film web (10);
- wherein the active substance depot areas (12) are defined such that the rows in the web direction (l) cannot be separated by means of a straight line without thereby cutting active substance depot areas (12);
- forming active substance depots by cutting (S2) the active substance-containing coating (2), followed by:
- severing (S4) the coated carrier film web (10) in the web direction (l) into two or more sub-webs (15a, 15b, 15c, 15d) such that each sub-web contains a row of active substance depots;
- wherein upon severing none of the active substance depots is cut;
- displacing (S6) the sub-webs (15a, 15b, 15c, 15d) relative to each other in the web direction (l) such that the parallel lying sub-webs in a direction 90° to the web direction (l) can be severed in straight lines such that individual portions are obtained each containing only one active substance depot and wherein upon severing none of the active substance depots is cut;
- and
- severing the sub-webs in strainght lines such that individual portions are obtained each containing only one active substance depot.
A device for producing systems for the transdermal or permucosal administration of active substances from a coated carrier film web (10) comprising a carrier film web (1) with an active substance-containing floating (2) adherent thereon, wherein active substance depot areas (12) are defined on the coated carrier film web (10) such that the active substance depot areas (12) are arranged in the web direction (l) of the coated carrier film web (10) in two or more rows such that the proportion of the surface of the coated carrier film web (10) that is not used as active substance depot area (12) by ignoring the rim zones of the coated carrier film web (10) is less than 39% of the total area of the coated carrier film web (10);
- wherein the active substance depot areas (12) are defined such that the rows in the web direction (l) cannot be separated by means of a straight line without thereby cutting active substance depot areas (12);
- the system comprising:
- a contouring facility (210) which is for severing the active substance-containing coating (2) to form active substance depots, followed by
- a separating facility (230) for severing the carrier film web (10) into two or more sub-webs (15a, 15b, 15c, 15d) that at leat partially laterally engage with one another, and
- an offset facility (240) designed to change the location of the sub-webs (15a, 15b, 15c, 15d) relative to each other such that none of the sub-webs laterally engages one of the other sub-webs;
- and
- means for displacing the individual sub-webs (15a, 15b, 15c, 15d) relative to each other in the web direction (l) of the coated carrier film web (10) such that crosswise to the web direction active substance depots (12) have no offset (Al) to each other in the web direction;
- and
- a cross cutting facility for severing the sub-webs in straight lines such that individual portions are obtained each containing only one active substance depot.
Dependencies are inferred from the claim text.