Chromatography systems with mobile phase generators
AssigneePerkinElmer Health Sciences, Inc.
InventorAndrew Tipler
Life of this patent
Estimating the term…
Abstract
Certain configurations of a gas chromatography system comprising an internal gas generator are described. In some instances, the gas chromatography system may comprise an internal hydrogen generator to provide hydrogen gas to a chromatography column for separation of analyte species. In certain examples, the gas chromatography system can be operated without any external gas inputs.
Claims26
A gas chromatography system comprising a housing comprising an injector and an internal gas generator inside the housing, wherein the injector is configured to fluidically couple to a gas chromatography column within the housing through a first internal fluid line, wherein the internal gas generator is configured to fluidically couple to the gas chromatography column through a second fluid line, wherein the internal gas generator is configured to generate hydrogen gas, and wherein the gas chromatography system is further configured to use the generated hydrogen gas from the internal gas generator as a carrier gas to separate analyte species using the gas chromatography column without using any externally introduced carrier gas.
A gas chromatography system comprising:
- a housing comprising an injector;
- and
- a plurality of gas generators comprising at least one internal gas generator inside the housing,
- wherein the injector is configured to fluidically couple to a gas chromatography column within the housing through a first internal fluid line,
- wherein the at least one internal gas generator is configured to fluidically couple to the gas chromatography column through a second fluid line,
- wherein the at least one internal gas generator is configured to generate hydrogen gas,
- wherein the gas chromatography system is configured to use the generated hydrogen from the at least one internal gas generator as a carrier gas for introduction and separation of analyte species,
- wherein the gas system chromatography system further comprises a detector and is further configured to use the generated hydrogen gas from the at least one has generator as a makeup gas for the detector, in which the detector is a flame ionization detector or a flame photometric detector, in which each of the plurality of gas generators is independently controlled to regulate pressure in the gas chromatography system, or in which the gas chromatography system is configured to control the pressure in the gas chromatography system without using a pneumatic pressure controller.
A gas chromatography system configured to separate analyte species using a gas chromatography column within a housing of the gas chromatography system, the gas chromatography system comprising:
- an injector coupled to the housing of the gas chromatography system, the injector configured to fluidically couple to the gas chromatography column to provide sample comprising the analyte species from the injector to the gas chromatography column;
- an internal gas generator within the housing of the gas chromatography system and configured to fluidically couple to each of the injector and the gas chromatography column to provide carrier gas generated by the internal gas generator to the injector and to the gas chromatography column to introduce the sample into the gas chromatography column and separate analyte species in the sample without using an externally introduced carrier gas;
- and
- a detector configured to fluidically couple to the gas chromatography column to receive separated analyte species from the gas chromatography column.
A gas chromatography system configured to separate analyte species using a chromatography column within a housing of the gas chromatography system, the gas chromatography system comprising:
- an injector coupled to the housing of the gas chromatography system, the injector configured to fluidically couple to the chromatography column to provide sample comprising the analyte species from the injector to the chromatography column;
- an internal gas generator within the housing of the gas chromatography system and configured to fluidically couple to the injector and the chromatography column to provide carrier gas generated by the internal gas generator to the injector and to the chromatography column;
- and
- a detector configured to fluidically couple to the chromatography column to receive separated analyte species from the chromatography column, the system further comprising a gas reservoir fluidically coupled to the internal gas generator and configured to store at least one gas generated by the internal gas generator, the system further comprising a second gas reservoir fluidically coupled to the internal gas generator, in which the gas reservoir receives a first gas from the internal gas generator and the second gas reservoir receives a second gas from the internal gas generator.
A gas chromatography system configured to separate analyte species using a chromatography column within a housing of the gas chromatography system, the gas chromatography system comprising:
- an injector coupled to the housing of the gas chromatography system, the injector configured to fluidically couple to the chromatography column to provide sample comprising the analyte species from the injector to the chromatography column;
- an internal gas generator within the housing of the gas chromatography system and configured to fluidically couple to the injector and the chromatography column to provide carrier gas generated by the internal gas generator to the injector and to the chromatography column;
- and
- a detector configured to fluidically couple to the chromatography column to receive separated analyte species from the chromatography column, in which the internal gas generator within the housing of the gas chromatography system comprises an electrolysis cell configured to electrolyze water to generate the hydrogen and the oxygen, the system further comprising a first port configured to receive the generated hydrogen and provide the generated hydrogen to a chromatography column and comprising a second port configured to receive the generated oxygen and provide the generated oxygen to the detector.
Dependencies are inferred from the claim text.