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US 10,752,613 B2Granted
Compounds and their use for reducing uric acid levels
AssigneeAcquist LLC
InventorsJohn J. Piwinski, Arshad Siddiqui, Raymond P. Warrell, Jr.
Life of this patent
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Abstract
Bifunctional compounds that increase uric acid excretion and reduce uric acid production, and monofunctional compounds that either increase uric acid excretion or reduce uric acid production. Methods of using these compounds for reducing uric acid levels in blood or serum, for treating disorders of uric acid metabolism, and for maintaining normal uric acid levels in blood or serum are also provided. Pharmaceutical compositions comprising the bifunctional and monofunctional compounds are also provided.
Claims18
A compound selected from the group consisting of
- a) compounds having a structure represented by Formula (I):
- wherein
- X is O or S;
- each Z is independently present or absent and, if present, is independently selected from —CF3, —OR2, and aryl, wherein R2 is H, alkyl or aryl;
- and;
- a, b, c, d, and e are each independently carbon, nitrogen, CH, or NH, with the proviso that 2 or 3 of a, b, c, d and e are nitrogen and Z is not connected directly to a nitrogen except that Z may optionally be connected to a nitrogen at a, b, c, d, or e by replacement of the hydrogen of an NH group when Z is phenyl;
- and
- b) tautomers of any of the foregoing compounds.
5 more elements
Dependencies are inferred from the claim text.