3,5-diamino-6-chloro-N—(N-(4-(4-(2-(hexyl(2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide
AssigneeParion Sciences, Inc.
InventorMichael R. Johnson
Life of this patent
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Abstract
The present invention relates to the compound of the formula: or pharmaceutically acceptable salts thereof, as well as compositions containing the same, processes for the preparation of the same, and therapeutic methods of use therefore in promoting hydration of mucosal surfaces and the treatment of diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, acute and chronic bronchitis, cystic fibrosis, emphysema, and pneumonia.
Claims16
A pharmaceutical composition comprising a compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, and an osmolyte.
The pharmaceutical composition of 2, wherein the hypertonic saline has a concentration of 4%-5% w/v.
A pharmaceutical composition comprising a compound of the following formula:
- or a pharmaceutically acceptable salt thereof, and hypertonic saline.
The pharmaceutical composition of 11, wherein the hypertonic saline has a concentration of 4%-5% w/v.
Dependencies are inferred from the claim text.