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US 10,751,431 B2Granted
Positron emission capsule for image-guided proton therapy
AssigneesNational Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center
InventorMamdooh Alqathami
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Abstract
Multi-modal imaging capsule for image-guided proton beam therapy, consisting of a biocompatible polymer layer, 18O-enriched water, and a contrast agent. The biocompatible capsule may be inserted near or inside a tumor under the guidance of X-ray, magnetic resonance, or ultrasonography imaging. Upon proton beam irradiation, the capsule emits positrons, allowing the tumor to be imaged and tracked by a PET detector.
Claims20
A positron emitter capsule comprising:
- a biocompatible encapsulating polymer layer;
- a volume of 18O-enriched water, wherein the 18O-enriched water is encapsulated by the biocompatible encapsulating polymer layer;
- and
- a contrast agent which is active under magnetic resonance imaging (MRI) or X-ray imaging.
1 more element
Dependencies are inferred from the claim text.